Technology Process of 1H-Pyrrole-3-acetic acid, 2-methyl-5-[(phenylmethoxy)carbonyl]-, methyl
ester
There total 4 articles about 1H-Pyrrole-3-acetic acid, 2-methyl-5-[(phenylmethoxy)carbonyl]-, methyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium nitrite, glacial acetic acid / H2O / 1 h / 5 °C
2: zinc, sodium acetate, acetic acid / H2O / 2 h / 78 °C
3: 90 percent / boron trifluoride etherate / 1.) 0 deg C, 15 min, 2.) 25 deg C, 1 h, 3.) 40 deg C, 1.5 h
4: 1.) thallium(III) nitrate trihydrate, 2.) concd. nitric acid / 1.) methanol, 30 deg C, 1 h, 2.) methanol, 30 deg C, 17 h
With
thallium(III) nitrate trihydrate; boron trifluoride diethyl etherate; nitric acid; sodium acetate; acetic acid; zinc; sodium nitrite;
In
water;
DOI:10.1021/jo00374a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: zinc, sodium acetate, acetic acid / H2O / 2 h / 78 °C
2: 90 percent / boron trifluoride etherate / 1.) 0 deg C, 15 min, 2.) 25 deg C, 1 h, 3.) 40 deg C, 1.5 h
3: 1.) thallium(III) nitrate trihydrate, 2.) concd. nitric acid / 1.) methanol, 30 deg C, 1 h, 2.) methanol, 30 deg C, 17 h
With
thallium(III) nitrate trihydrate; boron trifluoride diethyl etherate; nitric acid; sodium acetate; acetic acid; zinc;
In
water;
DOI:10.1021/jo00374a031
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / boron trifluoride etherate / 1.) 0 deg C, 15 min, 2.) 25 deg C, 1 h, 3.) 40 deg C, 1.5 h
2: 1.) thallium(III) nitrate trihydrate, 2.) concd. nitric acid / 1.) methanol, 30 deg C, 1 h, 2.) methanol, 30 deg C, 17 h
With
thallium(III) nitrate trihydrate; boron trifluoride diethyl etherate; nitric acid;
DOI:10.1021/jo00374a031
