2,5-DIMETHOXY-BETA-NITROSTYRENE

Base Information

• Chemical Name: 2,5-DIMETHOXY-BETA-NITROSTYRENE
• CAS No.: 40276-11-7
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.202
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID00418767
• Mol file: 40276-11-7.mol

Synonyms:Styrene,2,5-dimethoxy-b-nitro-(6CI,7CI);2,5-Dimethoxy-b-nitrostyrene;NSC 158921;NSC 610188;

Chemical Property of 2,5-DIMETHOXY-BETA-NITROSTYRENE

Chemical Property:

• Appearance/Colour: orange crystalline powder
• Vapor Pressure: 8.66E-05mmHg at 25°C
• Melting Point: 116-120 °C(lit.)
• Refractive Index: 1.564
• Boiling Point: 350.8oC at 760mmHg
• Flash Point: 163.2oC
• PSA: 64.28000
• Density: 1.197g/cm3
• LogP: 2.47440
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 209.06880783
• Heavy Atom Count: 15
• Complexity: 236

Purity/Quality:

99% ^*data from raw suppliers

(E)-1,4-Dimethoxy-2-(2-nitrovinyl)benzene ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OC)C=C[N+](=O)[O-]

Technology Process of 2,5-DIMETHOXY-BETA-NITROSTYRENE

There total 3 articles about 2,5-DIMETHOXY-BETA-NITROSTYRENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

nitromethane (75-52-5) + 2,5-dimethoxybenzaldehyde (93-02-7) → (E)-1,4-dimethoxy-2-(2-nitrovinyl) benzene (40276-11-7)

Guidance literature:

With ethylenediamine diacetic acid; In isopropyl alcohol; at 20 ℃; for 24h;

DOI:10.1016/j.vascn.2018.11.001

Reference yield:

nitromethane (75-52-5) + ethanol (64-17-5) + 2,5-dimethoxybenzaldehyde (93-02-7) → (E)-1,4-dimethoxy-2-(2-nitrovinyl) benzene (40276-11-7)

Guidance literature:

DOI:10.1002/biof.5520110404

Reference yield:

→ (E)-1,4-dimethoxy-2-(2-nitrovinyl) benzene (40276-11-7)

Guidance literature:

2,5-Dimethoxy-benzaldehyd/Eg., Nitromethan unter Zusatz von Ammoniumacetat;

DOI:10.1139/v67-166

upstream raw materials:

nitromethane

2,5-dimethoxybenzaldehyde

ethanol

Downstream raw materials:

2,5-dimethoxyphenethylamine

(4R,5S)-5-benzoyl-4-(2,5-dimethoxyphenyl)oxazolidin-2-one

(S)-4-[(S)-1-(2,5-dimethoxyphenyl)-2-nitroethyl]-2-(ethylthio)-4-isopropylthiazol-5(4H)-one

Refernces

• 1、 de Silva, Nilamuni H.,Pyreddy, Suneela,Blanch, Ewan W.,Hügel, Helmut M.,Maniam, Subashani. "Microwave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents". supporting information. . Retrieved 2021/07/07.
• 2、 Ravichandran, Veerasamy,Shalini, Sivadasan,Kumar, Krishnan Suresh,Rajak, Harish,Agrawal, Ram Kishore. "Design, synthesis and evaluation of thiourea derivatives as antimicrobial and antiviral agents". . p. 618 - 624. Retrieved 2019/06/25.