2-[4-(4-Fluorophenyl)piperazin-1-yl]ethan-1-ol

Base Information

• Chemical Name: 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethan-1-ol
• CAS No.: 90096-38-1
• Molecular Formula: C12H17FN2O
• Molecular Weight: 224.278
• DSSTox Substance ID: DTXSID10541358
• Wikidata: Q82417710

Synonyms:90096-38-1;2-[4-(4-Fluorophenyl)piperazin-1-yl]ethan-1-ol;1-Piperazineethanol, 4-(4-fluorophenyl)-;2-[4-(4-FLUOROPHENYL)PIPERAZIN-1-YL]ETHANOL;2-(4-(4-Fluorophenyl)piperazin-1-yl)ethan-1-ol;starbld0023353;2-[4-(4-fluorophenyl)-1-piperazinyl]ethanol;SCHEMBL10365486;DTXSID10541358;ONKAXBAMDYNOFH-UHFFFAOYSA-N;MFCD11613829;AKOS009561454;4-(4-fluorophenyl)-1-piperazineethanol;NS-02786;CS-0358650;AS-871/43477395;F1908-1791

Chemical Property of 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethan-1-ol

Chemical Property:

• PSA: 26.71000
• LogP: 0.94290
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 224.13249133
• Heavy Atom Count: 16
• Complexity: 199

Purity/Quality:

2-[4-(4-Fluorophenyl)piperazin-1-yl]ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCO)C2=CC=C(C=C2)F

Technology Process of 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethan-1-ol

There total 2 articles about 2-[4-(4-Fluorophenyl)piperazin-1-yl]ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(4-Fluorophenyl)piperazine (2252-63-3) + 2-bromoethanol (540-51-2) → 2-<4-(4-fluorophenyl)piperazin-1-yl>ethanol (90096-38-1)

Guidance literature:

With triethylamine; In chloroform; at 50 ℃;

DOI:10.1016/j.ejmech.2017.03.036

Reference yield:

potassium carbonate (584-08-7) + 1-(4-Fluorophenyl)piperazine (2252-63-3) + 2-bromoethanol (540-51-2) → 2-<4-(4-fluorophenyl)piperazin-1-yl>ethanol (90096-38-1)

Guidance literature:

In water; N,N-dimethyl-formamide;

Reference yield: 85.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + 2-<4-(4-fluorophenyl)piperazin-1-yl>ethanol (90096-38-1) → 2-<4-(4-fluorophenyl)piperazin-1-yl>ethyl acetoacetate (90096-18-7)

Guidance literature:

With triethylamine; at 95 ℃; for 3h;

DOI:10.1002/ardp.19973300109

upstream raw materials:

1-(4-Fluorophenyl)piperazine

2-bromoethanol

potassium carbonate

Downstream raw materials:

2-<4-(4-fluorophenyl)piperazin-1-yl>ethyl acetoacetate

Ethyl 4-[2-(4-{4-fluorophenyl}-1-piperazinyl)ethoxy]acetoacetate

4-(2-Chloro-phenyl)-2-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethoxymethyl}-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

2-[4-(4-fluorophenyl)-1-piperazinyl]ethyl methyl 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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