1-Benzyloxy-4-bromo-2,5-difluorobenzene

Base Information

• Chemical Name: 1-Benzyloxy-4-bromo-2,5-difluorobenzene
• CAS No.: 901238-24-2
• Molecular Formula: C13H9BrF2O
• Molecular Weight: 299.115
• Mol file: 901238-24-2.mol

Synonyms:1-benzyloxy-4-bromo-2,5-difluoro-benzene;4-bromo-2,5-difluorophenyl phenylmethyl ether;

Chemical Property of 1-Benzyloxy-4-bromo-2,5-difluorobenzene

Chemical Property:

• PSA: 9.23000
• LogP: 4.30630

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyloxy-4-bromo-2,5-difluorobenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyloxy-4-bromo-2,5-difluorobenzene

There total 2 articles about 1-Benzyloxy-4-bromo-2,5-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-bromo-2,5-difluoro phenol (486424-36-6) + benzyl bromide (100-39-0) → 1-(benzyloxy)-4-bromo-2,5-difluorobenzene (901238-24-2)

Guidance literature:

4-bromo-2,5-difluoro phenol; With caesium carbonate; In N,N-dimethyl-formamide; for 0.25h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

2,5-difluorophenol (2713-31-7) → 1-(benzyloxy)-4-bromo-2,5-difluorobenzene (901238-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; trifluoroacetic acid / 20 °C

2: potassium carbonate / acetonitrile / 20 °C

With bromine; potassium carbonate; trifluoroacetic acid; In acetonitrile;

DOI:10.1139/V10-143

Reference yield: 80.0%

1-(benzyloxy)-4-bromo-2,5-difluorobenzene (901238-24-2) + 8-(Prop-1-en-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol → C24H26F2O4

Guidance literature:

With palladium diacetate; N-cyclohexyl-cyclohexanamine; In 1,4-dioxane; water; for 12h; Reflux;

upstream raw materials:

4-bromo-2,5-difluoro phenol

benzyl bromide

2,5-difluorophenol

Downstream raw materials:

1-{2,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole

(4-benzyloxy-2,5-difluoro-phenyl)-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

C₁₅H₁₁BrF₂O₂

C₂₄H₂₇F₂NO₆