2-[(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl dihydrogen phosphate

Base Information

• Chemical Name: 2-[(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl dihydrogen phosphate
• CAS No.: 86626-01-9
• Molecular Formula: C₉H₁₃N₄O₅P
• Molecular Weight: 288.2
• Mol file: 86626-01-9.mol

Synonyms:7H-Pyrrolo[2,3-d]pyrimidine,ethanol deriv.; NSC 339178

Chemical Property of 2-[(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl dihydrogen phosphate

Chemical Property:

• Vapor Pressure: 2.2E-15mmHg at 25°C
• Boiling Point: 602.9°Cat760mmHg
• Flash Point: 318.4°C
• Density: 1.77g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl dihydrogen phosphate

There total 3 articles about 2-[(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

acyclotubercidin (86625-99-2) → 7-(2-hydroxyethoxymethyl)-4-dimethylaminopyrrolo<2,3-d>pyrimidine 2'-phosphate (86626-01-9)

Guidance literature:

With trimethyl phosphite; ammonium hydroxide; trichlorophosphate; at 0 - 5 ℃; for 1.5h;

Reference yield:

7-(benzoyloxyethoxymethyl)-4-chloropyrrolo<2,3-d>pyrimidine (86625-98-1) → 7-(2-hydroxyethoxymethyl)-4-dimethylaminopyrrolo<2,3-d>pyrimidine 2'-phosphate (86626-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / NH₃ / methanol / 8 h / 130 °C / high pressure

2: 41 percent / POCl₃, trimethylphosphate; NH₄OH / 1.5 h / 0 - 5 °C

With trimethyl phosphite; ammonium hydroxide; ammonia; trichlorophosphate; In methanol;

Reference yield:

4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 7-(2-hydroxyethoxymethyl)-4-dimethylaminopyrrolo<2,3-d>pyrimidine 2'-phosphate (86626-01-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 37 percent / 60percent NaH / dimethylformamide / 0.5 h / Ambient temperature

2: 47 percent / NH₃ / methanol / 8 h / 130 °C / high pressure

3: 41 percent / POCl₃, trimethylphosphate; NH₄OH / 1.5 h / 0 - 5 °C

With trimethyl phosphite; ammonium hydroxide; ammonia; sodium hydride; trichlorophosphate; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

acyclotubercidin

7-(benzoyloxyethoxymethyl)-4-chloropyrrolo<2,3-d>pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine