86625-99-2

Usage

Type of compound

chemical compound

Activities

antiviral and antineoplastic

Target enzymes

human immunodeficiency virus (HIV) and human T-lymphotropic virus type I (HTLV-I) reverse transcriptase

Classification

nucleoside analog

Function

potent inhibitor of reverse transcriptase

Potential applications

treatment of HIV and other viral infections, certain types of cancer

Status

experimental drug

Effectiveness

has shown promise in vitro and in animal studies

Upstream product

• 86625-98-1 7-(benzoyloxyethoxymethyl)-4-chloropyrrolo<2,3-d>pyrimidine 
• 114199-80-3 4-amino-2-(methylthio)-7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine 
• 114199-79-0 4-chloro-2-(methylthio)-7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine 
• 114199-78-9 4-chloro-2-(methylthio)-7-[(2-acetoxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine 
• 57564-94-0 2-(methylthio)-4-chloropyrrolo<2,3-d>pyrimidine 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 86626-01-9 7-(2-hydroxyethoxymethyl)-4-dimethylaminopyrrolo<2,3-d>pyrimidine 2'-phosphate 

Relevant academic research and scientific papers

Synthesis and antiviral activity of certain 4-substituted and 2,4-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines

Treatment of the sodium salt of 4-chloro-2-(methylthio)pyrrolo[2,3-d]pyrimidine (2) with (2-acetoxyethoxy)methyl bromide (3) has provided 4-chloro-2-(methylthio)-7-[2-acetoxyethoxy)methyl]pyrrolo[2,3-d]pyrim dine (4). Ammonolysis of 4 at room temperature

Preparation of 7-Substituted Pyrrolopyrimidines and 9-Substituted Purines as Potential Antiparasitic Agents

A series of six 7-substituted pyrrolopyrimidines and two 9-substituted purines were prepared and evaluated for potential antiparasitic activity.All were inactive against P. berghei in mice.Six of the target compounds were also evaluated for antitrypanosomal activity against T. rhodensiense in mice.All six compounds were also inactive in this screen.