(3R)-2,3,4,10-Tetrahydro-3-hydroxy-2,2,10-trimethyl-5H-pyrano[2,3-b]quinolin-5-one

Base Information

Chemical Name:(3R)-2,3,4,10-Tetrahydro-3-hydroxy-2,2,10-trimethyl-5H-pyrano[2,3-b]quinolin-5-one
CAS No.:62928-56-7
Molecular Formula:C15H17NO3
Molecular Weight:259.3
Hs Code.:
Mol file:62928-56-7.mol

Synonyms:(R)-3-Hydroxy-2,2,9-trimethyl-2,3,4,9-tetrahydro-1-oxa-9-aza-anthracen-10-one;(R)-3-hydroxy-2,2,10-trimethyl-2,3,4,10-tetrahydro-pyrano[2,3-b]quinolin-5-one;Folifin;ribalinine;(+)-(R)-ribalinine;folifine;

Suppliers and Price of (3R)-2,3,4,10-Tetrahydro-3-hydroxy-2,2,10-trimethyl-5H-pyrano[2,3-b]quinolin-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-2,3,4,10-Tetrahydro-3-hydroxy-2,2,10-trimethyl-5H-pyrano[2,3-b]quinolin-5-one

Chemical Property:

PSA：51.46000
LogP:1.61290

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3R)-2,3,4,10-Tetrahydro-3-hydroxy-2,2,10-trimethyl-5H-pyrano[2,3-b]quinolin-5-one

There total 7 articles about (3R)-2,3,4,10-Tetrahydro-3-hydroxy-2,2,10-trimethyl-5H-pyrano[2,3-b]quinolin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 316172-98-2
(-)-(3R)-geibalansine

: 74-88-4
methyl iodide

: 62928-56-7
(+)-(3R)-ribalinine

Guidance literature:: for 15h; Heating;
DOI:10.1039/b005285j

Reference yield:

: 88148-18-9
5-methoxy-2,2-dimethyl-(2H)-pyrano<2,3-b>quinoline

: 62928-56-7
(+)-(3R)-ribalinine

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / N-bromosuccinimide; water / tetrahydrofuran / 24 h / 20 °C

2: 36 percent

3: 82 percent / t-BuOK / tetrahydrofuran / 24 h / 20 °C

4: 87 percent / 10percent Pd/C / methanol / 20 °C

5: 100 percent / 15 h / Heating

With N-Bromosuccinimide; potassium tert-butylate; water; 10percent Pd/C; In tetrahydrofuran; methanol; 1: Addition / 2: Acylation / 3: Epoxidation / 4: Catalytic hydrogenation / 5: Methylation;
DOI:10.1039/b005285j

Reference yield:

: (+/-)-trans-3-bromo-4-hydroxy-3,4-dihydro-5-methoxy-2,2-dimethyl-2H-pyrano[2,3-b]quinoline

: 62928-56-7
(+)-(3R)-ribalinine

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent

2: 82 percent / t-BuOK / tetrahydrofuran / 24 h / 20 °C

3: 87 percent / 10percent Pd/C / methanol / 20 °C

4: 100 percent / 15 h / Heating

With potassium tert-butylate; 10percent Pd/C; In tetrahydrofuran; methanol; 1: Acylation / 2: Epoxidation / 3: Catalytic hydrogenation / 4: Methylation;
DOI:10.1039/b005285j