2-Hydroxy-5-trifluoromethylpyridine

Base Information

• Chemical Name: 2-Hydroxy-5-trifluoromethylpyridine
• CAS No.: 33252-63-0
• Molecular Formula: C6H4F3NO
• Molecular Weight: 163.099
• Hs Code.: 29339900
• Mol file: 33252-63-0.mol

Synonyms:2(1H)-Pyridone,5-(trifluoromethyl)- (8CI);2-Hydroxy-5-(trifluoromethyl)pyridine;5-(Trifluoromethyl)-2-pyridinol;5-(Trifluoromethyl)pyridin-2(1H)-one;5-Trifluoromethyl-2-hydroxypyridine;2(1H)-Pyridinone,5-(trifluoromethyl)-;

Chemical Property of 2-Hydroxy-5-trifluoromethylpyridine

Chemical Property:

• Appearance/Colour: Yellow to brown powder
• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 145-149 °C(lit.)
• Refractive Index: 1.457
• Boiling Point: 286.815 °C at 760 mmHg
• PKA: 9.55±0.10(Predicted)
• Flash Point: 127.262 °C
• PSA: 33.12000
• Density: 1.423 g/cm³
• LogP: 1.80600
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Soluble), Ethanol (Sparingly), Methanol (Sightly)

Purity/Quality:

98% ^*data from raw suppliers

2-Hydroxy-5-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-65-20/21/22-20/21
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Hydroxy-5-(trifluoromethyl)pyridine (cas# 33252-63-0) is a compound useful in organic synthesis.

Technology Process of 2-Hydroxy-5-trifluoromethylpyridine

There total 13 articles about 2-Hydroxy-5-trifluoromethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[(pentamethylcyclopentadienyl)Ir(5-trifuloromethyl-2-pyridonate)Cl] (1163304-58-2,1286718-14-6) → 2-hydroxy-5-(trifluoromethyl)pyridine (33252-63-0)

Guidance literature:

With hydrogen; In ⁽²⁾H₈-toluene; at 110 ℃; for 0.0833333h;

Reference yield: 97.0%

5-(trifluoromethyl)pyridin-2-yl pivalate (1448448-07-4) → 2-hydroxy-5-(trifluoromethyl)pyridine (33252-63-0)

Guidance literature:

With silver(I) acetate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 130 ℃;

DOI:10.1002/ejoc.201201151

Reference yield: 88.0%

2-chloro-5-trifluoromethylpyridine (52334-81-3) → 5-(trifluoromethyl)-2(1H)-pyridone (33252-63-0,79894-13-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 90 - 94 ℃;

upstream raw materials:

5-(trifluoromethyl)-2H-pyran-2-one

2-chloro-5-trifluoromethylpyridine

2-chloro-5-trifluoromethyl-pyridine

2-bromo-5-(trifluoromethyl)pyridine

Downstream raw materials:

2-(2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)acetic acid

3-bromo-5-(trifluoromethyl)pyridin-2-ol

3-bromo-5-(trifluoromethyl)pyridin-2(1H)-one

3-nitro-5-(trifluoromethyl)pyridin-2(1H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 33252-63-0 2-Hydroxy-5-trifluoromethylpyridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send