3-Piperidinemethanol, 1-[[3-(3-aminopropoxy)phenyl]methyl]-

Base Information

Chemical Name:3-Piperidinemethanol, 1-[[3-(3-aminopropoxy)phenyl]methyl]-
CAS No.:90287-78-8
Molecular Formula:C₁₆H₂₆N₂O₂
Molecular Weight:278.395
Hs Code.:
DSSTox Substance ID:DTXSID10441526

Synonyms:90287-78-8;3-Piperidinemethanol, 1-[[3-(3-aminopropoxy)phenyl]methyl]-;SCHEMBL10996208;DTXSID10441526

Suppliers and Price of 3-Piperidinemethanol, 1-[[3-(3-aminopropoxy)phenyl]methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Piperidinemethanol, 1-[[3-(3-aminopropoxy)phenyl]methyl]-

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:278.199428076
Heavy Atom Count:20
Complexity:263

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CN(C1)CC2=CC(=CC=C2)OCCCN)CO

Technology Process of 3-Piperidinemethanol, 1-[[3-(3-aminopropoxy)phenyl]methyl]-

There total 4 articles about 3-Piperidinemethanol, 1-[[3-(3-aminopropoxy)phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187816-88-2
2-{3-[3-(3-hydroxymethylpiperidin-1-ylmethyl)phenoxy]propyl}isoindole-1,3-dione

: 90287-78-8
{1-[3-(3-Amino-propoxy)-benzyl]-piperidin-3-yl}-methanol

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h; Heating;
DOI:10.1016/S0968-0896(97)00074-6

Reference yield:

: 4606-65-9
3-(hydroxymethy)piperidine

: 90287-78-8
{1-[3-(3-Amino-propoxy)-benzyl]-piperidin-3-yl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / ethanol / 16 h / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 4 h

3: H₂NNH₂*H₂O / ethanol / 2 h / Heating

With sodium tetrahydroborate; sodium hydride; hydrazine hydrate; In ethanol;
DOI:10.1248/cpb.45.116

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 90287-78-8
{1-[3-(3-Amino-propoxy)-benzyl]-piperidin-3-yl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / ethanol / 16 h / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 4 h

3: H₂NNH₂*H₂O / ethanol / 2 h / Heating

With sodium tetrahydroborate; sodium hydride; hydrazine hydrate; In ethanol;
DOI:10.1248/cpb.45.116