4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Base Information

Chemical Name:4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine
CAS No.:90358-16-0
Molecular Formula:C₇H₇ClN₄
Molecular Weight:182.612
Hs Code.:
DSSTox Substance ID:DTXSID50415908
Mol file:90358-16-0.mol

Synonyms:90358-16-0;4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine;4-Chloro-5-methyl-1H-pyrrolo[2,3-d]pyrimidin-2-amine;SCHEMBL1738453;7H-pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-5-methyl-;DTXSID50415908;XSTHCQQIOBGYKL-UHFFFAOYSA-N;MFCD13189356;AB68254;FT-0708968;D97102;2-amino-4-chloro-5-methyl-1h-pyrrolo[2,3-d]pyrimidine;InChI=1/C7H7ClN4/c1-3-2-10-6-4(3)5(8)11-7(9)12-6/h2H,1H3,(H3,9,10,11,12

Suppliers and Price of 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
4-chloro-5-methyl-7H-Pyrrolo[2,3-d]pyrimidin-2-amine 97.00%
25G
$ 8510.00

AccelPharmtech
4-chloro-5-methyl-7H-Pyrrolo[2,3-d]pyrimidin-2-amine 97.00%
5G
$ 4530.00

AccelPharmtech
4-chloro-5-methyl-7H-Pyrrolo[2,3-d]pyrimidin-2-amine 97.00%
1G
$ 2640.00

Abosyn
4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine 95%-98%
1g
$ 900.00

Total 5 raw suppliers

Chemical Property of 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Chemical Property:

Melting Point:225 - 228 °C (methanol)
PSA：67.59000
LogP:2.08310
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:182.0359239
Heavy Atom Count:12
Complexity:177

Purity/Quality:

97% ^*data from raw suppliers

4-chloro-5-methyl-7H-Pyrrolo[2,3-d]pyrimidin-2-amine 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CNC2=C1C(=NC(=N2)N)Cl

Technology Process of 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 1 articles about 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 65062-57-9
2-Amino-5-methyl-3H-pyrrolo<2,3-d>pyrimidin-4(7H)-on

: 90358-16-0
4-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine

Guidance literature:: With trichlorophosphate; for 4h; Heating;

Reference yield: 73.0%

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 90358-16-0
4-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine

: 193891-16-6
4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: With potassium hydroxide; In acetonitrile; for 0.25h; Ambient temperature;
DOI:10.1002/hlca.19970800406

Reference yield:

: 90358-16-0
4-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine

: 174463-02-6
N-(7-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / KOH, TDA-1 / acetonitrile / 0.25 h / Ambient temperature

2: 84 percent / 0.5 M NaOMe / 2 h / Heating

3: 80 percent / 2 N aq. NaOH / 10 h / Heating

4: pyridine / 0.25 h / Ambient temperature

5: pyridine / 3 h / Ambient temperature

6: 25 percent aq. NH₃ / 0.25 h

7: 91 percent / pyridine / 4 h / Ambient temperature

With pyridine; potassium hydroxide; ammonium hydroxide; sodium hydroxide; sodium methylate; In acetonitrile;
DOI:10.1002/hlca.19970800406