Carbamic acid, [(6R)-6-(6-heptenyl)-1,4,5,6-tetrahydro-1-[(E)-[[(1S)-1-(methoxymethyl)- 2-methylpropyl]imino]phenylmethyl]-4-oxo-3-pyridinyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(6R)-6-(6-heptenyl)-1,4,5,6-tetrahydro-1-[(E)-[[(1S)-1-(methoxymethyl)- 2-methylpropyl]imino]phenylmethyl]-4-oxo-3-pyridinyl]-, 1,1-dimethylethyl ester
CAS No.:904930-03-6
Molecular Formula:C30H45N3O4
Molecular Weight:511.705
Hs Code.:

Carbamic acid,
[(6R)-6-(6-heptenyl)-1,4,5,6-tetrahydro-1-[(E)-[[(1S)-1-(methoxymethyl)-
2-methylpropyl]imino]phenylmethyl]-4-oxo-3-pyridinyl]-, 1,1-dimethylethyl
ester

Synonyms:

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Chemical Property of Carbamic acid, [(6R)-6-(6-heptenyl)-1,4,5,6-tetrahydro-1-[(E)-[[(1S)-1-(methoxymethyl)- 2-methylpropyl]imino]phenylmethyl]-4-oxo-3-pyridinyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(6R)-6-(6-heptenyl)-1,4,5,6-tetrahydro-1-[(E)-[[(1S)-1-(methoxymethyl)- 2-methylpropyl]imino]phenylmethyl]-4-oxo-3-pyridinyl]-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [(6R)-6-(6-heptenyl)-1,4,5,6-tetrahydro-1-[(E)-[[(1S)-1-(methoxymethyl)- 2-methylpropyl]imino]phenylmethyl]-4-oxo-3-pyridinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 904929-79-9
(2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one

: 4248-19-5
tert-butyl carbazate

: 904930-03-6
tert-butyl (6R)-6-hept-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In toluene; at 90 ℃; for 48h;
DOI:10.1021/ol0609006

Reference yield:

: Trifluoro-methanesulfonate4-methoxy-1-{[(E)-(S)-1-methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;

: 904930-03-6
tert-butyl (6R)-6-hept-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert-butyllithium / diethyl ether; pentane / 1 h / -78 °C

1.2: MgBr₂*Et₂O / diethyl ether; pentane / 1 h / 20 °C

1.3: 83 percent / diethyl ether; pentane; CH₂Cl₂ / -20 °C

2.1: 92 percent / pyridine; iodine / CH₂Cl₂ / 4 h / 0 °C

3.1: 94 percent / Cs₂CO₃; CuI; N,N-dimethylethylenediamine / toluene / 48 h / 90 °C

With pyridine; copper(l) iodide; iodine; tert.-butyl lithium; caesium carbonate; N,N`-dimethylethylenediamine; In diethyl ether; dichloromethane; toluene; pentane;
DOI:10.1021/ol0609006

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 904930-03-6
tert-butyl (6R)-6-hept-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: CH₂Cl₂ / -78 - 20 °C

2.1: tert-butyllithium / diethyl ether; pentane / 1 h / -78 °C

2.2: MgBr₂*Et₂O / diethyl ether; pentane / 1 h / 20 °C

2.3: 83 percent / diethyl ether; pentane; CH₂Cl₂ / -20 °C

3.1: 92 percent / pyridine; iodine / CH₂Cl₂ / 4 h / 0 °C

4.1: 94 percent / Cs₂CO₃; CuI; N,N-dimethylethylenediamine / toluene / 48 h / 90 °C

With pyridine; copper(l) iodide; iodine; tert.-butyl lithium; caesium carbonate; N,N`-dimethylethylenediamine; In diethyl ether; dichloromethane; toluene; pentane;
DOI:10.1021/ol0609006