(2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one

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Chemical Name:(2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one
CAS No.:904929-79-9
Molecular Formula:C₂₅H₃₅IN₂O₂
Molecular Weight:522.47
Hs Code.:

Synonyms:(2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one

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Chemical Property of (2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one

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Technology Process of (2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one

There total 8 articles about (2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 904930-02-5
6-{(2R)-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,2,3,4-tetrahydropyridin-2-yl}hexanal

: 1779-49-3
Methyltriphenylphosphonium bromide

: 904929-79-9
(2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one

Guidance literature:: Methyltriphenylphosphonium bromide; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 1h;

6-{(2R)-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,2,3,4-tetrahydropyridin-2-yl}hexanal; In tetrahydrofuran; at -78 - 0 ℃; for 2.5h;
DOI:10.1021/ol0609006

Reference yield: 92.0%

: 2-hept-6-enyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-2,3-dihydropyridin-4(1H)-one

: 904929-79-9
(2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one

Guidance literature:: With pyridine; iodine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ol0609006

Reference yield:

: Trifluoro-methanesulfonate4-methoxy-1-{[(E)-(S)-1-methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;

: 904929-79-9
(2R)-2-hept-6-enyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-2,3-dihydropyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert-butyllithium / diethyl ether; pentane / 1 h / -78 °C

1.2: MgBr₂*Et₂O / diethyl ether; pentane / 1 h / 20 °C

1.3: 83 percent / diethyl ether; pentane; CH₂Cl₂ / -20 °C

2.1: 92 percent / pyridine; iodine / CH₂Cl₂ / 4 h / 0 °C

With pyridine; iodine; tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol0609006