3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, ethyl ester

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, ethyl ester
• CAS No.: 52851-60-2
• Molecular Formula: C14H15 N O4
• Molecular Weight: 261.277
• Hs Code.: 2933790090
• Mol file: 52851-60-2.mol

Synonyms:3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, ethyl ester

Chemical Property of 3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, ethyl ester

Chemical Property:

• Vapor Pressure: 4.84E-06mmHg at 25°C
• Boiling Point: 367.3°C at 760 mmHg
• Flash Point: 175.9°C
• PSA: 68.53000
• Density: 1.282g/cm³
• LogP: 1.90370

Purity/Quality:

98% ^*data from raw suppliers

1-ETHYL-1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, ethyl ester

There total 12 articles about 3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-ethyl-2-oxo-4-hydroxyquinoline-3-carboxylic acid ethyl ester potassium salt → ethyl 1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate (52851-60-2)

Guidance literature:

With hydrogenchloride; for 1h;

DOI:10.1007/BF01169641

Reference yield: 78.0%

2-[(2-Ethoxycarbonyl-acetyl)-ethyl-amino]-benzoic acid ethyl ester → ethyl 1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate (52851-60-2)

Guidance literature:

With potassium hydroxide; for 0.5h;

DOI:10.1007/BF00475251

Reference yield: 76.0%

ethyl 4-chloro-1-ethyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (169216-65-3) → ethyl 1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate (52851-60-2)

Guidance literature:

With sodium acetate; acetic anhydride; In acetic acid; for 100h; Heating;

DOI:10.1007/BF01176973

upstream raw materials:

ethyl iodide

2-oxo-3-ethoxycarbonyl-4-acetoxyquinoline

ethyl 4-chloro-1-ethyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

ethyl ester of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

Downstream raw materials:

C₁₉H₁₆FN₃O₄

C₁₉H₁₇N₃O₄

C₂₀H₁₉N₃O₄

C₁₉H₁₆BrN₃O₄

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