Synonyms:iodoethane
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Xn:Harmful;There total 267 articles about Iodoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 84.0%
Reference yield: 79.0%
Reference yield: 75.0%
The research aimed to develop a simple, direct, and efficient method for converting thioamides into thioesters, which are activated carboxylic acid derivatives with applications in synthetic chemistry. The study addressed the need for a reliable, multi-gram synthesis of thioesters and proposed a new route from thioamides that is mild, inexpensive, and experimentally straightforward. The method involved warming thioamides in an aqueous tetrahydrofuran (THF) solution containing an alkylating agent, leading to high yields and being scalable to multi-gram levels. The reactions were found to be tolerant of aryl ethers and acetals, and when volatile alkyl halides were used, products of approximately 95% purity could be obtained without chromatographic purification. Key chemicals used in the process included various thioamides, alkyl iodides, dialkyl sulfates, and activated alkyl bromides as alkylating agents, with methyl iodide (MeI), ethyl iodide (EtI), allyl bromide (allyl-Br), and benzyl bromide (BnBr) being specific examples. The study concluded that the developed method was effective for preparing thioesters from thioamides, offering a practical alternative to existing methods.
This research investigates the synthesis and characterization of thiosemicarbazone-S-alkyl ester ligands derived from 2/3-formylpyridine and their complexes with Zn(II) and Pd(II) ions. The study aims to explore the structural properties and coordination behavior of these ligands with metal ions, given the biological significance of thiosemicarbazones and their metal complexes. Key chemicals used include thiosemicarbazide, methyl iodide, ethyl iodide, 2-formylpyridine, ZnCl?, and Li?[PdCl?]. The ligands and their metal complexes were characterized using elemental analyses, IR and 1H NMR spectroscopy. The findings reveal that the thiosemicarbazone-S-alkyl esters can act as mono-, bi-, or tridentate ligands depending on the alkyl group and metal ion, with notable differences in coordination behavior between Zn(II) and Pd(II) complexes. The study concludes that the coordination properties of these ligands are influenced by the position of the pyridine nitrogen and the steric hindrance of the alkyl group, providing insights into the design of metal complexes with potential biological applications.
The study investigates the condensation reactions of isopropylpyrido[3,2-d]tropolones. The researchers explored various reactions involving these compounds. For instance, 8-isopropyl-2-methylpyrido[3,2-d]tropolone and 9-isopropyl-2-methylpyrido[3,2-d]tropolone reacted with benzaldehyde to produce 8-isopropyl-2-styrylpyrido[3,2-d]tropolone (VIa) and 9-isopropyl-2-styrylpyrido[3,2-d]tropolone (VIb) respectively. The compounds Va, Vb, and Vc, which are derivatives of isopropylpyrido[3,2-d]tropolones, reacted with o-phenylenediamine in acetic acid to yield quinoxaline derivatives such as the quinoxalo derivative of 8-isopropylpyrido[3,2-d]tropolone (VIIla) and the quinoxalo derivative of 8-isopropyl-2-methylpyrido[3,2-d]tropolone (VIIIb). Additionally, the reaction of 8-isopropyl-2-methylpyrido[3,2-d]tropolone (XIb) with phenylhydrazine in acetic acid resulted in the formation of yellow crystals (XIIb) with a pyrido[3,2-d]indolo[2,3-b]tropone structure. The study also attempted to prepare quaternary salts of 8-isopropylpyrido[3,2-d]tropolones by reaction with methyl iodide, ethyl iodide, and ethyl p-toluenesulfonate, but these attempts were unsuccessful. The researchers concluded that the condensation products have specific structures based on their observations and spectral data analysis.
The study reports the first synthesis of bisgermylene and bisstannylene with an acyclic structure. The synthesis was achieved through one-pot, two-step ligand substitution reactions starting from germanium and tin dichlorides. The key chemicals involved include 1,4-dioxane complexes of germanium dichloride (la) and tin dichloride (1b), lithium amide compounds derived from amines such as 1,1,1,3,3,3-hexamethyldisilazane and N,N'-bis(trimethylsilyl)-p-phenylenediamine. These lithium amides played crucial roles in the ligand substitution steps. The products, bisgermylene (5a) and bisstannylene (5b), were isolated by crystallization from diethyl ether and were found to be stable at ambient temperatures under an inert atmosphere. The study also explored the oxidative addition of these compounds to organic halides like ethyl iodide and ethyl bromide, yielding products 6a and 6b, which were characterized by their melting points and NMR spectra. The research aims to extend the understanding of organometallic chemistry involving germanium and tin compounds and their potential applications in polymer synthesis and other organometallic reactions.
The research focuses on the synthesis, antimicrobial activity, and quantitative structure-activity relationship (QSAR) analysis of new ethyl 3,4-dihydro-3-oxo-4,6,7-trisubstituted-2H-1,4-benzoxazine-2-acetate derivatives. The study aimed to develop novel antimicrobial agents to combat drug resistance and improve treatment outcomes for bacterial and fungal infections. The synthesis involved reactions with various o-aminophenols, monoethyl fumaryl chloride, potassium carbonate, and alkylating agents like methyliodide or ethyliodide. The structures of the synthesized compounds were confirmed using IR, 1H NMR, and mass spectral data. The antimicrobial activity was evaluated using the twofold serial dilution technique against different Gram-positive, Gram-negative bacteria, and Candida species, comparing the results with standard drugs. QSAR analysis was performed using multiple regression analysis to predict the lead optimization for antifungal activity against Candida krusei, considering physicochemical parameters and structural indicators. The research was supported by the Research Fund of Ankara University and employed a series of chemical and microbiological assays, along with statistical data processing, to achieve its objectives.
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