Pyridine, 2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylthio)-1H-imid azol-5-yl]-

Base Information

Chemical Name:Pyridine, 2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylthio)-1H-imid azol-5-yl]-
CAS No.:908381-35-1
Molecular Formula:C18H17F2N3OS
Molecular Weight:361.415
Hs Code.:

Synonyms:

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Chemical Property of Pyridine, 2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylthio)-1H-imid azol-5-yl]-

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Technology Process of Pyridine, 2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylthio)-1H-imid azol-5-yl]-

There total 3 articles about Pyridine, 2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylthio)-1H-imid azol-5-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 908382-45-6
4-(4-fluorophenyl)-5-(2-fluoro-4-pyridyl)-1-(2-methoxyethyl)-1,3-dihydro-2H-imidazole-2-thione

: 74-88-4
methyl iodide

: 908381-35-1
2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;
DOI:10.1055/s-2007-1000852

Reference yield: 52.0%

: 556-64-9
methyl thiocyanate

: 1015514-21-2
1-(4-fluorophenyl)-2-(2-fluoro-4-pyridyl)-2-[(2-methoxyethyl)amino]ethanone

: 908382-45-6
4-(4-fluorophenyl)-5-(2-fluoro-4-pyridyl)-1-(2-methoxyethyl)-1,3-dihydro-2H-imidazole-2-thione

: 908381-35-1
2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine

Guidance literature:: In N,N-dimethyl-formamide; for 0.583333h; Heating;
DOI:10.1055/s-2007-1000852

Reference yield: 47.0%

: 908381-46-4
4-[5-(4-fluorophenyl)-3-(2-methoxyethyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-ylamine

: 908381-35-1
2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine

Guidance literature:: 4-[5-(4-fluoro-phenyl)-3-(2-methoxyethyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-ylamine; With tetrafluoroboric acid; sodium nitrite; at 0 ℃;

at 45 ℃; for 1h; Further stages.;
DOI:10.1055/s-2007-1000852