1H-Thieno[2,3-c]pyrazole-5-carboxylic acid, 3-[[4-[(diethylamino)methyl]benzoyl]amino]-, 2-(4-chlorophenyl)-2-methylhydrazide

Base Information

• Chemical Name: 1H-Thieno[2,3-c]pyrazole-5-carboxylic acid, 3-[[4-[(diethylamino)methyl]benzoyl]amino]-, 2-(4-chlorophenyl)-2-methylhydrazide
• CAS No.: 909252-97-7
• Molecular Formula: C25H27ClN6O2S
• Molecular Weight: 511.047
• Mol file: 909252-97-7.mol

Synonyms:

Chemical Property of 1H-Thieno[2,3-c]pyrazole-5-carboxylic acid, 3-[[4-[(diethylamino)methyl]benzoyl]amino]-, 2-(4-chlorophenyl)-2-methylhydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Thieno[2,3-c]pyrazole-5-carboxylic acid, 3-[[4-[(diethylamino)methyl]benzoyl]amino]-, 2-(4-chlorophenyl)-2-methylhydrazide

There total 5 articles about 1H-Thieno[2,3-c]pyrazole-5-carboxylic acid, 3-[[4-[(diethylamino)methyl]benzoyl]amino]-, 2-(4-chlorophenyl)-2-methylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H36N6O4S + C30H35ClN6O4S → 4-diethylaminomethyl-N-[5-(N'-methyl-N'-phenylhydrazinocarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide trifluoroacetate (909252-95-5) + N-{5-[N'-(4-chlorophenyl)-N'-methylhydrazinocarbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}-4-diethylaminomethylbenzamide (909252-97-7)

Guidance literature:

In methanol; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

p-(chloromethyl)benzoyl chloride (876-08-4) → N-{5-[N'-(4-chlorophenyl)-N'-methylhydrazinocarbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}-4-diethylaminomethylbenzamide (909252-97-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / tetrahydrofuran / 18 h / 25 °C / Heating / reflux

2: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 80 h / 25 °C

3: methanol / 0.5 h / 100 °C / Microwave irradiation

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide (909252-87-5) → N-{5-[N'-(4-chlorophenyl)-N'-methylhydrazinocarbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}-4-diethylaminomethylbenzamide (909252-97-7)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 0 - 25 °C

2: potassium carbonate / tetrahydrofuran / 18 h / 25 °C / Heating / reflux

3: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 80 h / 25 °C

4: methanol / 0.5 h / 100 °C / Microwave irradiation

With dmap; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

p-(chloromethyl)benzoyl chloride

N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide

tert-butyl 3-amino-5-(N'-(4-chlorophenyl)-N'-methylhydrazinocarbonyl)thieno[2,3-c]pyrazole-1-carboxylate

tert-butyl 3-(4-chloromethylbenzoylamino)-5-(N'-(4-chlorophenyl)-N'-methylhydrazinocarbonyl)thieno[2,3-c]pyrazole-1-carboxylate