N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide

Base Information

• Chemical Name: N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide
• CAS No.: 909252-87-5
• Molecular Formula: C₁₃H₁₂ClN₅OS
• Molecular Weight: 321.79
• Mol file: 909252-87-5.mol

Synonyms:N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide

Chemical Property of N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide

There total 1 articles about N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N'-methyl-N'-phenyl(4-cyano-5-methanesulfinylthiophene)-2-carbohydrazide (909252-83-1) + N'-methyl-N'-phenyl(4-cyano-5-methanesulfonylthiophene)-2-carbohydrazide (909252-84-2) + N'-(4-chlorophenyl)-N'-methyl(4-cyano-5-methanesulfinylthiophene)-2-carbohydrazide (909252-85-3) + N'-(4-chlorophenyl)-N'-methyl(4-cyano-5-methanesulfonylthiophene)-2-carbohydrazide (909252-86-4) → N'-methyl-N'-phenyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide (909252-70-6) + N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide (909252-87-5)

Guidance literature:

N'-methyl-N'-phenyl(4-cyano-5-methanesulfinylthiophene)-2-carbohydrazide; N'-methyl-N'-phenyl(4-cyano-5-methanesulfonylthiophene)-2-carbohydrazide; N'-(4-chlorophenyl)-N'-methyl(4-cyano-5-methanesulfinylthiophene)-2-carbohydrazide; N'-(4-chlorophenyl)-N'-methyl(4-cyano-5-methanesulfonylthiophene)-2-carbohydrazide; With hydrazine; In tetrahydrofuran; ethanol; at 50 ℃; for 16h;

With hydrogenchloride; In ethanol; water; at 25 ℃; for 3.52h;

Reference yield:

N'-methyl-N'-phenyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide (909252-70-6) + N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide (909252-87-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-amino-5-(N'-methyl-N'-phenylhydrazinocarbonyl)-thieno[2,3-c]pyrazole-1-carboxylate (909252-69-3) + tert-butyl 3-amino-5-(N'-(4-chlorophenyl)-N'-methylhydrazinocarbonyl)thieno[2,3-c]pyrazole-1-carboxylate (909252-82-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 25 ℃;

Reference yield:

N'-(4-chlorophenyl)-N'-methyl(3-amino-1H-thieno[2,3-c]pyrazole)-5-carbohydrazide (909252-87-5) → 4-[(methylphenylamino)methyl]-N-[5-(N'-methyl-N'-phenylhydrazinocarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide (909253-18-5)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 0 - 25 °C

2: potassium carbonate / tetrahydrofuran / 18 h / 25 °C / Heating / reflux

3: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 360 h / 25 °C

4: methanol / 0.5 h / 100 °C / Microwave irradiation

With dmap; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

N'-methyl-N'-phenyl(4-cyano-5-methanesulfinylthiophene)-2-carbohydrazide

N'-methyl-N'-phenyl(4-cyano-5-methanesulfonylthiophene)-2-carbohydrazide

N'-(4-chlorophenyl)-N'-methyl(4-cyano-5-methanesulfinylthiophene)-2-carbohydrazide

N'-(4-chlorophenyl)-N'-methyl(4-cyano-5-methanesulfonylthiophene)-2-carbohydrazide

Downstream raw materials:

tert-butyl 3-amino-5-(N'-methyl-N'-phenylhydrazinocarbonyl)-thieno[2,3-c]pyrazole-1-carboxylate

tert-butyl 3-amino-5-(N'-(4-chlorophenyl)-N'-methylhydrazinocarbonyl)thieno[2,3-c]pyrazole-1-carboxylate

4-[(methylphenylamino)methyl]-N-[5-(N'-methyl-N'-phenylhydrazinocarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide

N-{5-[N'-(4-chlorophenyl)-N'-methylhydrazinocarbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}-4-diethylaminomethylbenzamide