1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[(phenylmethoxy)carbonyl]amino]propyl]-4-(2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[(phenylmethoxy)carbonyl]amino]propyl]-4-(2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-
CAS No.:910447-68-6
Molecular Formula:C35H50F2N2O6Si
Molecular Weight:660.874
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]
-2-[[(phenylmethoxy)carbonyl]amino]propyl]-4-(2-propenyloxy)-,
1,1-dimethylethyl ester, (2R,4R)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[(phenylmethoxy)carbonyl]amino]propyl]-4-(2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[(phenylmethoxy)carbonyl]amino]propyl]-4-(2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[(phenylmethoxy)carbonyl]amino]propyl]-4-(2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)-

There total 7 articles about 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[(phenylmethoxy)carbonyl]amino]propyl]-4-(2-propenyloxy)-, 1,1-dimethylethyl ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 877078-90-5
(2S,3S)-2-(3,5-difluorobenzyl)-3-((2R,4R)-4-(allyloxy)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-(tert-butyldimethylsilyloxy)propanoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 910447-68-6
(2R,4R)-tert-butyl 4-(allyloxy)-2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propyl)pyrrolidine-1-carboxylate

Guidance literature:: (2S,3S)-2-(3,5-difluorobenzyl)-3-((2R,4R)-4-(allyloxy)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-(tert-butyldimethylsilyloxy)propanoic acid; With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; In toluene;

benzyl alcohol; With N-ethyl-N,N-diisopropylamine; In toluene; at 70 ℃; for 16h;

Reference yield:

: 877078-49-4
(S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one

: 910447-68-6
(2R,4R)-tert-butyl 4-(allyloxy)-2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

2: 2,6-dimethylpyridine / dichloromethane

3: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water

4: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / toluene / 75 °C

5: 75 °C

With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; diphenyl phosphoryl azide; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene; 4: Curtius rearrangement;
DOI:10.1016/j.bmcl.2011.06.109

Reference yield:

: 877078-47-2
(2R,4R)-tert-butyl 4-(allyloxy)-2-formylpyrrolidine-1-carboxylate

: 910447-68-6
(2R,4R)-tert-butyl 4-(allyloxy)-2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

2: 2,6-dimethylpyridine / dichloromethane

3: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water

4: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / toluene / 75 °C

5: 75 °C

With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; diphenyl phosphoryl azide; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene; 4: Curtius rearrangement;
DOI:10.1016/j.bmcl.2011.06.109