1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[3-(methoxycarbonyl)-5-methylbenzoyl]amino]propyl]-4-propoxy-, 1,1-dimethylethyl ester, (2R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[3-(methoxycarbonyl)-5-methylbenzoyl]amino]propyl]-4-propoxy-, 1,1-dimethylethyl ester, (2R,4R)-
CAS No.:910447-75-5
Molecular Formula:C37H54F2N2O7Si
Molecular Weight:704.927
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]
-2-[[3-(methoxycarbonyl)-5-methylbenzoyl]amino]propyl]-4-propoxy-,
1,1-dimethylethyl ester, (2R,4R)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[3-(methoxycarbonyl)-5-methylbenzoyl]amino]propyl]-4-propoxy-, 1,1-dimethylethyl ester, (2R,4R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[3-(methoxycarbonyl)-5-methylbenzoyl]amino]propyl]-4-propoxy-, 1,1-dimethylethyl ester, (2R,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[3-(methoxycarbonyl)-5-methylbenzoyl]amino]propyl]-4-propoxy-, 1,1-dimethylethyl ester, (2R,4R)-

There total 1 articles about 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-3-(3,5-difluorophenyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy] -2-[[3-(methoxycarbonyl)-5-methylbenzoyl]amino]propyl]-4-propoxy-, 1,1-dimethylethyl ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 910447-74-4
(2R,4R)-tert-butyl 2-((1S,2S)-2-(3-bromo-5-(methoxycarbonyl)benzamido)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propyl)-4-propoxypyrrolidine-1-carboxylate

: 823-96-1
Trimethylboroxine

: 910447-75-5
(2R,4R)-tert-butyl 2-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)-2-(3-(methoxycarbonyl)-5-methylbenzamido)propyl)-4-propoxypyrrolidine-1-carboxylate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 60 - 100 ℃;

Reference yield:

: 910447-75-5
(2R,4R)-tert-butyl 2-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)-2-(3-(methoxycarbonyl)-5-methylbenzamido)propyl)-4-propoxypyrrolidine-1-carboxylate

: 910447-76-6
3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)-5-methylbenzoic acid

Guidance literature:: (2R,4R)-tert-butyl 2-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)-2-(3-(methoxycarbonyl)-5-methylbenzamido)propyl)-4-propoxypyrrolidine-1-carboxylate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; water; In tetrahydrofuran; methanol; diethyl ether;