1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxy-5-methylbenzoyl)amino]-3-(3,5-difluorophenyl) -1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxy-5-methylbenzoyl)amino]-3-(3,5-difluorophenyl) -1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-
CAS No.:910447-76-6
Molecular Formula:C36H52F2N2O7Si
Molecular Weight:690.9
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[(1S,2S)-2-[(3-carboxy-5-methylbenzoyl)amino]-3-(3,5-difluorophenyl)
-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-,
1-(1,1-dimethylethyl) ester, (2R,4R)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxy-5-methylbenzoyl)amino]-3-(3,5-difluorophenyl) -1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxy-5-methylbenzoyl)amino]-3-(3,5-difluorophenyl) -1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxy-5-methylbenzoyl)amino]-3-(3,5-difluorophenyl) -1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

There total 1 articles about 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxy-5-methylbenzoyl)amino]-3-(3,5-difluorophenyl) -1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910447-75-5
(2R,4R)-tert-butyl 2-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)-2-(3-(methoxycarbonyl)-5-methylbenzamido)propyl)-4-propoxypyrrolidine-1-carboxylate

: 910447-76-6
3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)-5-methylbenzoic acid

Guidance literature:: (2R,4R)-tert-butyl 2-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)-2-(3-(methoxycarbonyl)-5-methylbenzamido)propyl)-4-propoxypyrrolidine-1-carboxylate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; water; In tetrahydrofuran; methanol; diethyl ether;

Reference yield: 95.0%

: 910447-76-6
3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)-5-methylbenzoic acid

: 63126-47-6,76946-27-5,84025-81-0,135523-48-7
(2R)-methoxymethylpyrrolidine

: 910447-94-8
(2R,4R)-tert-butyl 2-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)-2-(3-((R)-2-(methoxymethyl)pyrrolidine-1-carbonyl)-5-methylbenzamido)propyl)-4-propoxypyrrolidine-1-carboxylate

Guidance literature:: 3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)-5-methylbenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 0.333333h;

(2R)-methoxymethylpyrrolidine; In dichloromethane; at 20 ℃;

Reference yield: 90.0%

: 910447-76-6
3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)-5-methylbenzoic acid

: 142-84-7
di-n-propylamine

: 910447-96-0
C₄₂H₆₅F₂N₃O₆Si

Guidance literature:: 3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)-5-methylbenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 0.333333h;

di-n-propylamine; In dichloromethane; at 20 ℃; for 6h;