1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxybenzoyl)amino]-3-(3,5-difluorophenyl)-1-[[(1,1- dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxybenzoyl)amino]-3-(3,5-difluorophenyl)-1-[[(1,1- dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-
CAS No.:910447-84-6
Molecular Formula:C35H50F2N2O7Si
Molecular Weight:676.874
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[(1S,2S)-2-[(3-carboxybenzoyl)amino]-3-(3,5-difluorophenyl)-1-[[(1,1-
dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl)
ester, (2R,4R)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxybenzoyl)amino]-3-(3,5-difluorophenyl)-1-[[(1,1- dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxybenzoyl)amino]-3-(3,5-difluorophenyl)-1-[[(1,1- dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

Chemical Property:

Purity/Quality:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxybenzoyl)amino]-3-(3,5-difluorophenyl)-1-[[(1,1- dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-

There total 1 articles about 1-Pyrrolidinecarboxylic acid, 2-[(1S,2S)-2-[(3-carboxybenzoyl)amino]-3-(3,5-difluorophenyl)-1-[[(1,1- dimethylethyl)dimethylsilyl]oxy]propyl]-4-propoxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910447-83-5
(2R,4R)-tert-butyl 2-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)-2-(3-(methoxycarbonyl)benzamido)propyl)-4-propoxypyrrolidine-1-carboxylate

: 910447-84-6
3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)benzoic acid

Guidance literature:: (2R,4R)-tert-butyl 2-((1S,2S)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)-2-(3-(methoxycarbonyl)benzamido)propyl)-4-propoxypyrrolidine-1-carboxylate; With methanol; lithium hydroxide; water; at 20 ℃; for 24h;

With hydrogenchloride; water; In methanol; diethyl ether;

Reference yield: 87.0%

: 910447-84-6
3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)benzoic acid

: 618-36-0
rac-methylbenzylamine

: 910448-01-0
C₄₃H₅₉F₂N₃O₆Si

Guidance literature:: 3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 0.333333h;

rac-methylbenzylamine; In dichloromethane; at 20 ℃;

Reference yield: 84.0%

: 910447-84-6
3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)benzoic acid

: 403-40-7
1-(4-fluorophenyl)ethylamine

: 910448-02-1
C₄₃H₅₈F₃N₃O₆Si

Guidance literature:: 3-(((1S,2S)-1-((2R,4R)-1-(tert-butoxycarbonyl)-4-propoxypyrrolidin-2-yl)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propan-2-yl)carbamoyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 0.333333h;

1-(4-fluorophenyl)ethylamine; In dichloromethane; at 20 ℃;