Technology Process of 1-Propanone,
3-[4-(3-amino-2-hydroxypropoxy)-3-ethyl-5-methylphenyl]-1-(3-ethyl-4,5,
6,7-tetrahydro-5,5-dimethylbenzo[c]thien-1-yl)-
There total 12 articles about 1-Propanone,
3-[4-(3-amino-2-hydroxypropoxy)-3-ethyl-5-methylphenyl]-1-(3-ethyl-4,5,
6,7-tetrahydro-5,5-dimethylbenzo[c]thien-1-yl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia;
In
methanol;
at 65 ℃;
for 18h;
Sealed tube;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diethyl ether / 0.25 h / 20 - 26 °C
2: hydrogenchloride / ethanol; isopropyl alcohol / 1.67 h / 20 °C
3: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 5 h / 20 °C / 1125.11 Torr
4: hydrogenchloride / isopropyl alcohol; water / 20 h / 20 °C
5: ammonia / methanol / 18 h / 65 °C / Sealed tube
With
hydrogenchloride; palladium 10% on activated carbon; ammonia; hydrogen;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; water; isopropyl alcohol;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 750.08 Torr
2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Cooling with ice
2.2: 0.83 h / 15 - 20 °C
3.1: oxalyl dichloride / chloroform / 1 h / 20 - 25 °C
4.1: sodium; ethanol / tetrahydrofuran / 1 h / 20 °C
5.1: sodium; ethanol / 0.25 h / 50 - 75 °C
6.1: water; lithium hydroxide / ethanol / 70 °C
7.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C
7.2: 3 h / -78 °C
8.1: diethyl ether / 0.25 h / 20 - 26 °C
9.1: hydrogenchloride / ethanol; isopropyl alcohol / 1.67 h / 20 °C
10.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 5 h / 20 °C / 1125.11 Torr
11.1: hydrogenchloride / isopropyl alcohol; water / 20 h / 20 °C
12.1: ammonia / methanol / 18 h / 65 °C / Sealed tube
With
hydrogenchloride; oxalyl dichloride; ethanol; palladium 10% on activated carbon; potassium tert-butylate; ammonia; water; hydrogen; tert.-butyl lithium; sodium; lithium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; chloroform; water; ethyl acetate; isopropyl alcohol; tert-butyl alcohol; pentane;
DOI:10.1021/jm401456d
