Technology Process of Benzo[c]thiophene-1-carboxylic acid,
3-ethyl-4,5,6,7-tetrahydro-5,5-dimethyl-
There total 8 articles about Benzo[c]thiophene-1-carboxylic acid,
3-ethyl-4,5,6,7-tetrahydro-5,5-dimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.166667h;
ethyl iodide;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 3h;
DOI:10.1021/jm401456d
- Guidance literature:
-
5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.166667h;
ethyl iodide;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 3h;
With
citric acid;
In
tetrahydrofuran; methanol; water; pentane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 750.08 Torr
2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Cooling with ice
2.2: 0.83 h / 15 - 20 °C
3.1: oxalyl dichloride / chloroform / 1 h / 20 - 25 °C
4.1: sodium; ethanol / tetrahydrofuran / 1 h / 20 °C
5.1: sodium; ethanol / 0.25 h / 50 - 75 °C
6.1: water; lithium hydroxide / ethanol / 70 °C
7.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C
7.2: 3 h / -78 °C
With
oxalyl dichloride; ethanol; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; tert.-butyl lithium; sodium; lithium hydroxide;
In
tetrahydrofuran; ethanol; chloroform; ethyl acetate; tert-butyl alcohol; pentane;
DOI:10.1021/jm401456d
![5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid](/Databaselist/images/loading.webp)
