Neojusticin B

Base Information

• Chemical Name: Neojusticin B
• CAS No.: 17803-12-2
• Molecular Formula: C22H18O7
• Molecular Weight: 394.37412
• Hs Code.: 2932999099
• Mol file: 17803-12-2.mol

Synonyms:Justicindin A;NEOJUSTICIN B;neousticin A;justicidin C;

Chemical Property of Neojusticin B

Chemical Property:

• PSA: 72.45000
• LogP: 3.93170

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Neojusticin B

There total 27 articles about Neojusticin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

potassium (3,4-(methylenedioxy)phenyl)trifluoroborate + 6,7,9-trimethoxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl methanesulfonate (1621253-46-0) → justicidin C (17803-12-2)

Guidance literature:

With palladium diacetate; caesium carbonate; ruphos; In tetrahydrofuran; water; tert-butyl alcohol; at 85 ℃; for 17h;

DOI:10.1002/ejoc.201601611

Reference yield: 91.0%

potassium (3,4-(methylenedioxy)phenyl)trifluoroborate + 9-methoxy-8-oxo-6,8-dihydrofuro[3′,4′:6,7]naphtho[2,3-d][1,3]-dioxol-5-yl methanesulfonate → justicidin C (17803-12-2)

Guidance literature:

With palladium diacetate; caesium carbonate; ruphos; In tetrahydrofuran; water; tert-butyl alcohol; at 85 ℃; for 17h;

DOI:10.1002/ejoc.201601611

Reference yield: 86.0%

6,7,9‐trimethoxy‐1‐oxo‐1,3‐dihydronaphtho[2,3‐c]furan‐4‐yl trifluoromethanesulfonate + 3,4-(methylenedioxy)-benzeneboronic acid (94839-07-3) → justicidin C (17803-12-2)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ardp.202000479

upstream raw materials:

4-(benzo[d][1,3]dioxol-5-yl)-9-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one

methyl iodide

2-bromo-4,5-dimethoxybenzaldehyde dimethyl acetal

5,6-Dimethoxy-3-(1,3-benzodioxol-5-yl)isobenzofuran-1(3H)-one

Refernces

• 1、 Kim, Taejung,Jeong, Kyu Hyuk,Kang, Ki Sung,Nakata, Masaya,Ham, Jungyeob. "An Optimized and General Synthetic Strategy To Prepare Arylnaphthalene Lactone Natural Products from Cyanophthalides". . p. 1704 - 1712. Retrieved 2017/04/13.
• 2、 Kobayashi, Kazuhiro,Maeda, Kouji,Uneda, Tomokazu,Morikawa, Osamu,Konishi, Hisatoshi. "A simple method for the synthesis of 4-aryl-9-oxynaphthofuranone lignans". . p. 443 - 446. Retrieved 2007/10/03.