1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[[(2-methyl-1-oxo-2-phenylpropyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[[(2-methyl-1-oxo-2-phenylpropyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-
• CAS No.: 911113-73-0
• Molecular Formula: C36H53N3O7
• Molecular Weight: 639.833
• Mol file: 911113-73-0.mol

Synonyms:

Chemical Property of 1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[[(2-methyl-1-oxo-2-phenylpropyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[[(2-methyl-1-oxo-2-phenylpropyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

There total 16 articles about 1-Pyrrolidinecarboxylic acid, 3-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methylethyl)amino]meth yl]-4-[[(2-methyl-1-oxo-2-phenylpropyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,4R)-3-aminomethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (911113-78-5) + 2-methyl-2-phenylpropionic acid (826-55-1) → (3R,4R)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-[(2-methyl-2-phenyl-propionylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (911113-73-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

4-methoxy-3-(3-methoxy-propoxy)-benzoic acid methyl ester (895240-49-0) → (3R,4R)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-[(2-methyl-2-phenyl-propionylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (911113-73-0)

Guidance literature:

Multi-step reaction with 7 steps

1: methanol; sodium hydroxide; water / 18 h / 20 °C

2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 3 h / Heating / reflux

3: tetrabutyl ammonium fluoride / tetrahydrofuran

4: triethylamine / 0.33 h / -20 °C

5: sodium azide / N,N-dimethyl-formamide / 70 °C

6: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With methanol; sodium hydroxide; sodium azide; tetrabutyl ammonium fluoride; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(3S,4S)-3,4-bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (895245-30-4,1393732-25-6,895245-31-5) → (3R,4R)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-[(2-methyl-2-phenyl-propionylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (911113-73-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: Dess-Martin periodane / dichloromethane; water

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5.42 h

4.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 3 h / Heating / reflux

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran

6.1: triethylamine / 0.33 h / -20 °C

7.1: sodium azide / N,N-dimethyl-formamide / 70 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

9.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With sodium azide; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium tris(acetoxy)borohydride; sodium hydride; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

(3R,4R)-3-aminomethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

2-methyl-2-phenylpropionic acid

4-methoxy-3-(3-methoxy-propoxy)-benzoic acid methyl ester

4-methoxy-3-(3-methoxy-propoxy)benzoic acid

Refernces