1-Pyrrolidinecarboxylic acid, 3-(aminomethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methyl ethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 3-(aminomethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methyl ethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-
CAS No.:911113-78-5
Molecular Formula:C26H43N3O6
Molecular Weight:493.644
Hs Code.:

1-Pyrrolidinecarboxylic acid,
3-(aminomethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methyl
ethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 3-(aminomethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methyl ethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 3-(aminomethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methyl ethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)-

There total 15 articles about 1-Pyrrolidinecarboxylic acid, 3-(aminomethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-methyl ethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911113-76-3
(3S,4R)-3-azidomethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 911113-78-5
(3R,4R)-3-aminomethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield:

: 895240-49-0
4-methoxy-3-(3-methoxy-propoxy)-benzoic acid methyl ester

: 911113-78-5
(3R,4R)-3-aminomethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; sodium hydroxide; water / 18 h / 20 °C

2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 3 h / Heating / reflux

3: tetrabutyl ammonium fluoride / tetrahydrofuran

4: triethylamine / 0.33 h / -20 °C

5: sodium azide / N,N-dimethyl-formamide / 70 °C

6: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

With methanol; sodium hydroxide; sodium azide; tetrabutyl ammonium fluoride; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 895240-50-3
4-methoxy-3-(3-methoxy-propoxy)benzoic acid

: 911113-78-5
(3R,4R)-3-aminomethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 3 h / Heating / reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran

3: triethylamine / 0.33 h / -20 °C

4: sodium azide / N,N-dimethyl-formamide / 70 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

With sodium azide; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;