6,7-Dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:6,7-Dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:87213-01-2
Molecular Formula:C18H22ClNO2
Molecular Weight:319.8258
Hs Code.:
DSSTox Substance ID:DTXSID201007423

Synonyms:87213-01-2;6,7-Dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride;1,2,3,4-Tetrahydro-6,7-dimethoxy-3-(4-methylphenyl)isoquinoline hydrochloride;Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-3-(4-methylphenyl)-, hydrochloride;6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride;DTXSID201007423;LS-85936;6,7-Dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6,7-Dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

Vapor Pressure:3.28E-07mmHg at 25°C
Boiling Point:418.4°Cat760mmHg
Flash Point:175.8°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:319.1339066
Heavy Atom Count:22
Complexity:327

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2CC3=CC(=C(C=C3CN2)OC)OC.Cl

Technology Process of 6,7-Dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 5 articles about 6,7-Dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 87213-01-2
6,7-dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / AlCl₃ / 1.) 15 deg C, 6.5 h, 2.) R_.T_. overnight

2: 98 percent formic acid / 12 h / 170 - 180 °C

3: 66 percent / POCl₃ / toluene / 4.5 h / Heating

4: 1.) NaBH₄, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; formic acid; trichlorophosphate; In toluene;
DOI:10.1135/cccc19831447

Reference yield:

: 87203-56-3
2-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)ethanone

: 87213-01-2
6,7-dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent formic acid / 12 h / 170 - 180 °C

2: 66 percent / POCl₃ / toluene / 4.5 h / Heating

3: 1.) NaBH₄, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; formic acid; trichlorophosphate; In toluene;
DOI:10.1135/cccc19831447

Reference yield:

: 65884-32-4
N-<2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl>formamide

: 87213-01-2
6,7-dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / POCl₃ / toluene / 4.5 h / Heating

2: 1.) NaBH₄, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; trichlorophosphate; In toluene;
DOI:10.1135/cccc19831447