6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide

Base Information

Chemical Name:6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide
CAS No.:87203-96-1
Molecular Formula:C16H17 N O2 . Br H
Molecular Weight:0
Hs Code.:
DSSTox Substance ID:DTXSID401007417
ChEMBL ID:CHEMBL1713230
Mol file:87203-96-1.mol

Synonyms:87203-96-1;6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide;1,2,3,4-Tetrahydro-3-(4-methylphenyl)-6,7-isoquinolinediol hydrobromide;6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-3-(4-methylphenyl)-, hydrobromide;C16H17NO2.BrH;MLS001179392;CHEMBL1713230;REGID_for_CID_3070964;C16-H17-N-O2.Br-H;DTXSID401007417;LS-85632;SMR000475859;3-(4-methylphenyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol;3-(4-Methylphenyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol--hydrogen bromide (1/1)

Suppliers and Price of 6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6,7-DIHYDROXY-3-(4-TOLYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE 95.00%
5MG
$ 495.59

Total 3 raw suppliers

Chemical Property of 6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide

Chemical Property:

Vapor Pressure:5.01E-09mmHg at 25°C
Boiling Point:458.5°C at 760 mmHg
Flash Point:174.4°C
PSA：52.49000
LogP:4.08010
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:335.05209
Heavy Atom Count:20
Complexity:301

Purity/Quality:: 6,7-DIHYDROXY-3-(4-TOLYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2CC3=CC(=C(C=C3CN2)O)O.Br

Technology Process of 6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide

There total 6 articles about 6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 87213-01-2
6,7-dimethoxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 87203-96-1
6,7-dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide

Guidance literature:: With hydrogen bromide; at 100 ℃; for 6.5h;
DOI:10.1135/cccc19831447

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 87203-96-1
6,7-dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / AlCl₃ / 1.) 15 deg C, 6.5 h, 2.) R_.T_. overnight

2: 98 percent formic acid / 12 h / 170 - 180 °C

3: 66 percent / POCl₃ / toluene / 4.5 h / Heating

4: 1.) NaBH₄, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.

5: 95 percent / 46 percent hydrobromic acid / 6.5 h / 100 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; formic acid; hydrogen bromide; trichlorophosphate; In toluene;
DOI:10.1135/cccc19831447

Reference yield:

: 87203-56-3
2-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)ethanone

: 87203-96-1
6,7-dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent formic acid / 12 h / 170 - 180 °C

2: 66 percent / POCl₃ / toluene / 4.5 h / Heating

3: 1.) NaBH₄, 5M NaOH, 2.) HCl / 1.) ethanol, reflux, 6 h, 2.) ether.

4: 95 percent / 46 percent hydrobromic acid / 6.5 h / 100 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; formic acid; hydrogen bromide; trichlorophosphate; In toluene;
DOI:10.1135/cccc19831447