ethyl 2-(acetylamino)-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Base Information

• Chemical Name: ethyl 2-(acetylamino)-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
• CAS No.: 91421-24-8
• Molecular Formula: C₁₃H₁₅NO₄S
• Molecular Weight: 281.332
• Mol file: 91421-24-8.mol

Synonyms:ethyl 2-acetylamino-4,5,6,7-tetrahydro-7-oxobenzo[b]thiophene-3-carboxylate;2-Acetylamino-7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester;2-Acetylamino-3-ethoxycarbonyl-7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene;ethyl 2-(acetylamino)-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate;

Chemical Property of ethyl 2-(acetylamino)-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Chemical Property:

• PSA: 100.71000
• LogP: 2.47520

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-acetamido-7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

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Technology Process of ethyl 2-(acetylamino)-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

There total 2 articles about ethyl 2-(acetylamino)-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.9%

ethyl 2-acetylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (5919-29-9) → 2-Acetylamino-3-ethoxycarbonyl-7-oxo-4,5,6,7-tetrahydrobenzothiophene (91421-24-8)

Guidance literature:

With potassium dichromate; In acetic acid; 1. 65-80 deg C; 2. 20 deg C, 2 h;

DOI:10.1007/BF00505954

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 2-Acetylamino-3-ethoxycarbonyl-7-oxo-4,5,6,7-tetrahydrobenzothiophene (91421-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

2: Ce⁽²⁺⁾*2O₄S^(2-); acetic acid / chloroform

With Ce⁽²⁺⁾*2O₄S^(2-); acetic acid; In chloroform;

DOI:10.1016/j.bmcl.2012.05.062

Reference yield: 89.0%

2-Acetylamino-3-ethoxycarbonyl-7-oxo-4,5,6,7-tetrahydrobenzothiophene (91421-24-8) → ethyl 2-acetamido-6-bromo-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (128811-90-5)

Guidance literature:

With bromine; In chloroform; for 1.83333h; Heating / reflux;

upstream raw materials:

ethyl 2-acetylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Downstream raw materials:

ethyl 2-acetamido-6-bromo-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

2-amino-3-ethoxycarbonyl-7-oxo-4,5,6,7-tetrahydrobenzothiophene

ethyl 2-acetylamino-6,6-dibromo-4,5,6,7-tetrahydro-7-oxobenzo[b]thiophene-3-carboxylate

2-Acetylamino-7-chloro-6-formyl-4,5-dihydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

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