Tris(4-dimethylaminophenyl)phosphine

Base Information

• Chemical Name: Tris(4-dimethylaminophenyl)phosphine
• CAS No.: 1104-21-8
• Molecular Formula: C24H30 N3 P
• Molecular Weight: 391.496
• Hs Code.: 2921590090
• European Community (EC) Number: 214-163-2
• NSC Number: 158459
• DSSTox Substance ID: DTXSID40911626
• Nikkaji Number: J217.218F
• Wikidata: Q82881772
• Mol file: 1104-21-8.mol

Synonyms:1104-21-8;Tris(4-dimethylaminophenyl)phosphine;4,4',4''-phosphinetriyltris[N,N-dimethylaniline];4-bis[4-(dimethylamino)phenyl]phosphanyl-N,N-dimethylaniline;EINECS 214-163-2;4,4',4''-Phosphinetriyltris(N,N-dimethylaniline);4,4',4''-Phosphinidynetris[n,n-dimethyl-benzenamine;Benzenamine, 4,4',4''-phosphinidynetris(N,N-dimethyl-;Benzenamine, 4,4',4''-phosphinidynetris[N,N-dimethyl-;NSC158459;SCHEMBL735682;C24H30N3P;DTXSID40911626;Tris(p-Dimethylaminophenyl)phosphine;EINECS 250-201-4;Tri[4-(dimethylamino)phenyl]phosphine;AKOS024262758;tris-(p-dimethylaminophenyl}-phosphine;NSC 158459;NSC-158459;4,4',4''-Phosphanetriyltris(N,N-dimethylaniline);4-bis(4-dimethylaminophenyl)phosphanyl-N,N-dimethyl-aniline;P(c1ccc(cc1)N(C)C)(c2ccc(cc2)N(C)C)c3ccc(cc3)N(C)C

Chemical Property of Tris(4-dimethylaminophenyl)phosphine

Chemical Property:

• Boiling Point: 518.7°Cat760mmHg
• Flash Point: 267.5°C
• PSA: 23.31000
• Density: g/cm³
• LogP: 3.64280
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 391.21773497
• Heavy Atom Count: 28
• Complexity: 376

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,4'',4''''-Phosphinidynetris[N,N-dimethyl-benzenamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)P(C2=CC=C(C=C2)N(C)C)C3=CC=C(C=C3)N(C)C
• Uses: 4,4'',4''''-Phosphinidynetris[N,N-dimethyl-benzenamine can be used for anti-tumor properties.

Technology Process of Tris(4-dimethylaminophenyl)phosphine

There total 8 articles about Tris(4-dimethylaminophenyl)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-bromo-N,N-dimethylaniline (586-77-6) → tris(p-dimethylaminophenyl)phosphine (1104-21-8)

Guidance literature:

4-bromo-N,N-dimethylaniline; With magnesium; lithium chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With phosphorus tribromide; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1002/chem.201502166

Reference yield: 48.0%

N,N-dimethyl-aniline (121-69-7,77733-26-7) → tris(p-dimethylaminophenyl)phosphine (1104-21-8)

Guidance literature:

With phosphorus tribromide; In benzene; 1) 20 deg C, 2 d 2) 24h, reflux;

Reference yield:

N,N-dimethyl-aniline (121-69-7,77733-26-7) + trichlorophosphate (10025-87-3,12599-09-6,63736-95-8,39380-77-3) → bis(p-(dimethylamino)phenyl)phosphonic acid (7439-52-3) + 4,4'-methylene-bis(N,N-dimethylaniline) (101-61-1) + tris(p-dimethylaminophenyl)phosphine (1104-21-8)

Guidance literature:

at 130 ℃; nachfolgenden Behandeln mit verd.Natronlauge;

upstream raw materials:

(4-dimethylamino-phenyl)-phosphonous acid dichloride

4-dimethylaminophenyllithium

N,N-dimethyl-aniline

4-bromo-N,N-dimethylaniline

Downstream raw materials:

[4-(2-benzothiazol-2-yl-vinyl)-benzyl]-tris-(4-dimethylamino-phenyl)-phosphonium; bromide

Tris-(4-dimethylamino-phenyl)-<2,7-dibrom-fluorenyliden-(9)>-phosphoran

N-phenyl-P,P,P-trisphospha-λ⁵-azene

C₃₁H₃₆N₃P

Refernces

• 1、 Hanimann. "". . p. 845. Retrieved 1876.
• 2、 Brune, Hans Albert,Falck, Manfred,Hemmer, Reinhard,Schmidtberg, Guenter,Alt, Helmut G.. "Syntheses and Spectroscopic Investigations of Substituted cis- and trans-Dichlorobis(triphenylphospane)platinum(II) Compounds". . p. 2791 - 2802. Retrieved 2007/10/02.