Technology Process of Methanone,
[6-(hydroxymethyl)-3-pyridinyl][3-[(4-methoxyphenyl)methoxy]-5-[1-[tris(1
-methylethyl)silyl]-1H-indol-4-yl]phenyl]-
There total 8 articles about Methanone,
[6-(hydroxymethyl)-3-pyridinyl][3-[(4-methoxyphenyl)methoxy]-5-[1-[tris(1
-methylethyl)silyl]-1H-indol-4-yl]phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanol; water; potassium carbonate;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C
1.2: 1 h / -78 - 0 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
3.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 24 h / Heating / reflux
4.1: water; potassium carbonate / methanol / 2 h / 20 °C
With
potassium phosphate; n-butyllithium; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex;
In
1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; water;
3.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ethanol; sulfuric acid; sodium nitrite / 3.25 h / Heating / reflux
2.1: potassium hydroxide; tetrabutylammomium bromide / tetramethylurea (TMU) / 49 h / 20 °C
3.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C
3.2: 1 h / -78 - 0 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
5.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 24 h / Heating / reflux
6.1: water; potassium carbonate / methanol / 2 h / 20 °C
With
potassium hydroxide; potassium phosphate; n-butyllithium; ethanol; sulfuric acid; tetrabutylammomium bromide; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium nitrite;
2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex;
In
1,4-dioxane; methanol; tetramethylurea (TMU); diethyl ether; hexane; dichloromethane; water;
5.1: Suzuki Coupling;