Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester

Base Information

Chemical Name:Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester
CAS No.:915411-90-4
Molecular Formula:C₄₀H₄₆N₂O₅Si
Molecular Weight:662.901
Hs Code.:

Synonyms:Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester

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Chemical Property of Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester

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Technology Process of Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester

There total 7 articles about Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 690632-17-8
4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-(triisopropylsilyl)-1H-indole

: 915411-89-1
acetic acid 5-[3-bromo-5-(4-methoxy-benzyloxy)-benzoyl]-pyridin-2-ylmethyl ester

: 915411-90-4
Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester

Guidance literature:: With potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; In 1,4-dioxane; water; for 24h; Heating / reflux;

Reference yield:

: 915410-93-4
1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene

: 915411-90-4
Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C

1.2: 1 h / -78 - 0 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

3.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 24 h / Heating / reflux

With potassium phosphate; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; In 1,4-dioxane; diethyl ether; hexane; dichloromethane; water; 3.1: Suzuki Coupling;

Reference yield:

: 6311-60-0
3,5-dibromonitrobenzene

: 915411-90-4
Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; tetrabutylammomium bromide / tetramethylurea (TMU) / 49 h / 20 °C

2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C

2.2: 1 h / -78 - 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

4.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 24 h / Heating / reflux

With potassium hydroxide; potassium phosphate; n-butyllithium; tetrabutylammomium bromide; 3-chloro-benzenecarboperoxoic acid; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; In 1,4-dioxane; tetramethylurea (TMU); diethyl ether; hexane; dichloromethane; water; 4.1: Suzuki Coupling;