5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile

Base Information

• Chemical Name: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile
• CAS No.: 916454-59-6
• Molecular Formula: C₁₁H₁₄BNO₂S
• Molecular Weight: 235.115
• Hs Code.: 2934999090
• European Community (EC) Number: 874-292-0
• DSSTox Substance ID: DTXSID40694402
• Wikidata: Q82623483
• Mol file: 916454-59-6.mol

Synonyms:916454-59-6;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile;4-CYANOTHIOPHEN-2-BORONIC ACID PINACOL ESTER;MFCD09952056;4-Cyanothiophene-2-boronic acid pinacol ester;SCHEMBL13868374;DTXSID40694402;OXYRAUHWTSONAV-UHFFFAOYSA-N;AKOS015946140;PS-12986;CS-0246086;FT-0702228;EN300-316822;A850674;J-516204;4-cyanothiophen-2-boronic acid pinacol ester, AldrichCPR;Z1650405748;5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophene-3-carbonitrile;5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)THIOPHENE-3-CARBONITRILE

Chemical Property of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile

Chemical Property:

• Boiling Point: 346.8±27.0 °C(Predicted)
• PSA: 70.49000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 1.91898
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 235.0838300
• Heavy Atom Count: 16
• Complexity: 320

Purity/Quality:

97% ^*data from raw suppliers

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC(=CS2)C#N
• Uses: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile is used to prepare azaisoindolinone derivatives for use as SYK inhibitors.

Technology Process of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile

There total 7 articles about 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

C17H25B2NO4S (916454-58-5) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile (916454-59-6)

Guidance literature:

With methanol; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In dichloromethane; at 55 ℃; for 5h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.5b01588

Reference yield: 8.0%

C17H25B2NO4S (916454-58-5) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile (916454-59-6) + 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile (463336-26-7)

Guidance literature:

With palladium diacetate; acetic acid; at 30 ℃; for 25h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.5b01588

Reference yield:

3-thiophenecarbonitrile (1641-09-4) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile (916454-59-6) + 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carbonitrile (463336-26-7)

Guidance literature:

(1,5-cyclooctadiene)(methoxy)iridium(I) dimer; (S,S)-4,4'-bis(phenylmethyl)-2,2',5,5'-tetrahydro-2,2'-bioxazole; In diethyl ether; at 20 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

3-thiophenecarbonitrile

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

C₁₇H₂₅B₂NO₄S

bis(pinacol)diborane

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