1-Cyclohexene-1-carboxylicacid, 4-[(1S,3S)-3-hydroxy-1,5-dimethylhexyl]-, methyl ester, (4R)-

Base Information

Chemical Name:1-Cyclohexene-1-carboxylicacid, 4-[(1S,3S)-3-hydroxy-1,5-dimethylhexyl]-, methyl ester, (4R)-
CAS No.:64314-14-3
Molecular Formula:C16H28 O3
Molecular Weight:268.39172
Hs Code.:

Synonyms:1-Cyclohexene-1-carboxylicacid, 4-(3-hydroxy-1,5-dimethylhexyl)-, methyl ester, [4R-[4R*(1S*,3S*)]]-;(+)-Epijuvabiol; (4R,1'S,3'S)-Epijuvabiol; Epijuvabiol

Suppliers and Price of 1-Cyclohexene-1-carboxylicacid, 4-[(1S,3S)-3-hydroxy-1,5-dimethylhexyl]-, methyl ester, (4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Cyclohexene-1-carboxylicacid, 4-[(1S,3S)-3-hydroxy-1,5-dimethylhexyl]-, methyl ester, (4R)-

Chemical Property:

PSA：46.53000
LogP:3.31910

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Cyclohexene-1-carboxylicacid, 4-[(1S,3S)-3-hydroxy-1,5-dimethylhexyl]-, methyl ester, (4R)-

There total 27 articles about 1-Cyclohexene-1-carboxylicacid, 4-[(1S,3S)-3-hydroxy-1,5-dimethylhexyl]-, methyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 80373-80-4
(R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarboxylic acid methyl ester

: 64314-14-3
Epijuvabiol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 7h; Heating;
DOI:10.1021/jo00339a054

Reference yield: 48.0%

: 145353-92-0
methyl (1'R,4R)-4-(2'-formyl-1'-methylethyl)cyclohex-1-ene-1-carboxylate

: 926-62-5
isobutylmagnesium bromide

: 58493-52-0,60134-56-7,60497-70-3,64314-14-3,76549-67-2,80373-62-2
methyl (4R,1'R,3'RS)-(+)-4-(1',5'-dimethyl-3'-hydroxyhexyl)-1-cyclohexenecarboxylate

Guidance literature:: In tetrahydrofuran; at -45 ℃; for 3h;

Reference yield:

: tert-Butyl-[(1S,3S)-1-isobutyl-3-((R)-4-methyl-cyclohex-3-enyl)-butoxy]-diphenyl-silane

: 64314-14-3
Epijuvabiol

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

2: 92 percent / diethylaluminum 2,2,6,6-tetramethylpiperidide / benzene / 3 h / 0 °C

3: 30 percent / lithium diethylamide / diethyl ether

4: 65 percent / PBr₃ / tetrahydrofuran / 0 °C

5: 88 percent / 2-nitropropane, KOH / H₂O; tetrahydrofuran; propan-2-ol / 1 h / 40 - 50 °C

6: 87 percent / manganese dioxide / acetic acid / 12 h / 22 °C

7: 88 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 7 h / Heating

With manganese(IV) oxide; potassium hydroxide; diethyl(2,2,6,6-tetramethylpiperidino)aluminium; 2-nitropropane; lithium diethylamide; tetrabutyl ammonium fluoride; phosphorus tribromide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid; isopropyl alcohol; benzene;
DOI:10.1021/jo00339a054