(R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde

Base Information

Chemical Name:(R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde
CAS No.:80373-77-9
Molecular Formula:C₃₁H₄₄O₂Si
Molecular Weight:476.775
Hs Code.:

Synonyms:(R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde

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Chemical Property of (R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde

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Technology Process of (R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde

There total 5 articles about (R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 80373-74-6
[(1S,3S)-3-((R)-4-Bromomethyl-cyclohex-3-enyl)-1-isobutyl-butoxy]-tert-butyl-diphenyl-silane

: 80373-77-9
(R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde

Guidance literature:: With potassium hydroxide; 2-nitropropane; In tetrahydrofuran; water; isopropyl alcohol; at 40 - 50 ℃; for 1h;
DOI:10.1021/jo00339a054

Reference yield:

: tert-Butyl-[(1S,3S)-1-isobutyl-3-((R)-4-methyl-cyclohex-3-enyl)-butoxy]-diphenyl-silane

: 80373-77-9
(R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

2: 92 percent / diethylaluminum 2,2,6,6-tetramethylpiperidide / benzene / 3 h / 0 °C

3: 30 percent / lithium diethylamide / diethyl ether

4: 65 percent / PBr₃ / tetrahydrofuran / 0 °C

5: 88 percent / 2-nitropropane, KOH / H₂O; tetrahydrofuran; propan-2-ol / 1 h / 40 - 50 °C

With potassium hydroxide; diethyl(2,2,6,6-tetramethylpiperidino)aluminium; 2-nitropropane; lithium diethylamide; phosphorus tribromide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; isopropyl alcohol; benzene;
DOI:10.1021/jo00339a054

Reference yield:

: tert-Butyl-[(1S,3S)-1-isobutyl-3-((R)-6-methyl-7-oxa-bicyclo[4.1.0]hept-3-yl)-butoxy]-diphenyl-silane

: 80373-77-9
(R)-4-[(1S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyl]-cyclohex-1-enecarbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / diethylaluminum 2,2,6,6-tetramethylpiperidide / benzene / 3 h / 0 °C

2: 30 percent / lithium diethylamide / diethyl ether

3: 65 percent / PBr₃ / tetrahydrofuran / 0 °C

4: 88 percent / 2-nitropropane, KOH / H₂O; tetrahydrofuran; propan-2-ol / 1 h / 40 - 50 °C

With potassium hydroxide; diethyl(2,2,6,6-tetramethylpiperidino)aluminium; 2-nitropropane; lithium diethylamide; phosphorus tribromide; In tetrahydrofuran; diethyl ether; water; isopropyl alcohol; benzene;
DOI:10.1021/jo00339a054