Acyclovir IMpurity C

Base Information

• Chemical Name: Acyclovir IMpurity C
• CAS No.: 91702-61-3
• Molecular Formula: C8H11N5O3
• Molecular Weight: 225.207
• Mol file: 91702-61-3.mol

Synonyms:acycloguanosine;UNII-5QK1Y89K2H;

Chemical Property of Acyclovir IMpurity C

Chemical Property:

• Melting Point: >280 °C (decomp)
• PKA: 9.46±0.20(Predicted)
• PSA: 120.04000
• Density: 1.77±0.1 g/cm3(Predicted)
• LogP: -0.98940

Purity/Quality:

99% ^*data from raw suppliers

N7-[(2-Hydroxyethoxy)methyl)guanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N7-[(2-Hydroxyethoxy)methyl)guanine is the 7-isomeric impurity of the antiviral drug Acyclovir (A192400).

Technology Process of Acyclovir IMpurity C

There total 8 articles about Acyclovir IMpurity C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

7-<(2-acetoxyethoxy)methyl>-N2-acetylguanine (91702-60-2) → 7-(2-Hydroxyethoxymethyl)guanine (91702-61-3)

Guidance literature:

With methylamine; at 80 ℃; for 0.5h;

DOI:10.1007/BF00766638

Reference yield: 70.0%

7-[[2-(p-methoxyphenyloxy)ethoxy]methyl]guanine (374678-34-9) → 7-(2-Hydroxyethoxymethyl)guanine (91702-61-3)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; acetonitrile; at 0 - 25 ℃; for 1h;

DOI:10.1021/jm010216r

Reference yield: 0.5%

2-acetoxyethyl acetoxymethyl ether (59278-00-1) + acetic anhydride (108-24-7) + G (118-00-3) → acycloguanosine (59277-89-3) + 7-(2-Hydroxyethoxymethyl)guanine (91702-61-3)

Guidance literature:

With sodium hydroxide; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1.) 100 deg C, 20 h, 2.) room temperature, overnight;

DOI:10.1080/15257779508012376

upstream raw materials:

7-<(2-acetoxyethoxy)methyl>-N²-acetylguanine

2-acetoxyethyl acetoxymethyl ether

acetic anhydride

G