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CAS No.: | 91702-61-3 |
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Name: | Acyclovir IMpurity C |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C8H11N5O3 |
Molecular Weight: | 225.207 |
Synonyms: | acycloguanosine;UNII-5QK1Y89K2H; |
Density: | 1.77±0.1 g/cm3(Predicted) |
Melting Point: | >280 °C (decomp) |
PSA: | 120.04000 |
LogP: | -0.98940 |
7-<(2-acetoxyethoxy)methyl>-N2-acetylguanine
7-(2-Hydroxyethoxymethyl)guanine
Conditions | Yield |
---|---|
With methylamine at 80℃; for 0.5h; | 82% |
7-[[2-(p-methoxyphenyloxy)ethoxy]methyl]guanine
7-(2-Hydroxyethoxymethyl)guanine
Conditions | Yield |
---|---|
With ammonium cerium(IV) nitrate In water; acetonitrile at 0 - 25℃; for 1h; | 70% |
With NH4Ca(NO3)3 In water; acetonitrile | 70% |
2-acetoxyethyl acetoxymethyl ether
acetic anhydride
A
acycloguanosine
B
7-(2-Hydroxyethoxymethyl)guanine
Conditions | Yield |
---|---|
With sodium hydroxide; toluene-4-sulfonic acid 1.) 100 deg C, 20 h, 2.) room temperature, overnight; Yield given. Multistep reaction; | A n/a B 0.5% |
2-amino-1,9-dihydro-6H-purin-6-one
7-(2-Hydroxyethoxymethyl)guanine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: (NH4)2SO4 / 24 h / Heating 2: 3.54 g / acetonitrile / 7 h / 25 °C 3: 88 percent / dimethylformamide / 8 h / 25 °C 4: 82 percent / dimethylformamide / 25 °C 5: 70 percent / ceric ammonium nitrate / acetonitrile; H2O / 1 h / 0 - 25 °C View Scheme |
6-Trimethylsilanyloxy-9H-purin-2-ylamine
7-(2-Hydroxyethoxymethyl)guanine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 3.54 g / acetonitrile / 7 h / 25 °C 2: 88 percent / dimethylformamide / 8 h / 25 °C 3: 82 percent / dimethylformamide / 25 °C 4: 70 percent / ceric ammonium nitrate / acetonitrile; H2O / 1 h / 0 - 25 °C View Scheme |
7-[(2-chloroethoxy)methyl]guanine
7-(2-Hydroxyethoxymethyl)guanine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 82 percent / dimethylformamide / 25 °C 2: 70 percent / ceric ammonium nitrate / acetonitrile; H2O / 1 h / 0 - 25 °C View Scheme |
9-(triphenylmethyl)guanine
7-(2-Hydroxyethoxymethyl)guanine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88 percent / dimethylformamide / 8 h / 25 °C 2: 82 percent / dimethylformamide / 25 °C 3: 70 percent / ceric ammonium nitrate / acetonitrile; H2O / 1 h / 0 - 25 °C View Scheme |
2,9-diacetylguanine
7-(2-Hydroxyethoxymethyl)guanine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) p-toluenesulfonic acid / 1.) AcOH, 2.) toluene, reflux, 16 h 2: 82 percent / aq. MeNH2 / 0.5 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: 22 percent / p-toluenesulfonic acid / 1.) 120-125 deg C, 2.) 150 deg C, 45 min 2: 82 percent / aq. MeNH2 / 0.5 h / 80 °C View Scheme |
7-(2-Hydroxyethoxymethyl)guanine
7-[(2-chloroethoxy)methyl]guanine
Conditions | Yield |
---|---|
With thionyl chloride In N,N,N,N,N,N-hexamethylphosphoric triamide at 20℃; for 24h; | 61.9% |
7-(2-Hydroxyethoxymethyl)guanine
methyl iodide
7-(2-Hydroxyethoxymethyl)-9-methylguaninium Hydroiodide
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; | 31% |