4-(ETHYLTHIO)PHENYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 4-(ETHYLTHIO)PHENYLMAGNESIUM BROMIDE
• CAS No.: 917382-51-5
• Molecular Formula: C8H9BrMgS
• Molecular Weight: 241.43100
• Mol file: 917382-51-5.mol

Synonyms:p-Ethylmercapto-phenylmagnesiumbromid;4-(Ethylthio)phenylmagnesium bromide 0.5 M in Tetrahydrofuran;4-ethylthiophenyl magnesium bromide;

Chemical Property of 4-(ETHYLTHIO)PHENYLMAGNESIUM BROMIDE

Chemical Property:

• PSA: 25.30000
• LogP: 3.44440

Purity/Quality:

95% ^*data from raw suppliers

4-(Ethylthio)phenylmagnesiumbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(ETHYLTHIO)PHENYLMAGNESIUM BROMIDE

There total 2 articles about 4-(ETHYLTHIO)PHENYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

FeCl3 *6H2O + 1-bromo-4-ethylthiobenzene (30506-30-0) → bis(4-ethylthiophenyl)disulfide (151426-22-1) + 4-(ethylthio)phenylmagnesium bromide (917382-51-5)

Guidance literature:

With hydrogen sulfide;

Reference yield:

1-bromo-4-ethylthiobenzene (30506-30-0) + magnesium (7439-95-4) → 4-(ethylthio)phenylmagnesium bromide (917382-51-5)

Guidance literature:

With ethylene dibromide; In tetrahydrofuran; at 50 ℃; for 1.5h; Heating / reflux;

Reference yield:

tert-butyl 2-{(Z)-[(tert-butylsulfinyl)imino]methyl}piperidine-1-carboxylate (917382-50-4) + 4-(ethylthio)phenylmagnesium bromide (917382-51-5) → tert-butyl (R*)-2-{(R*)-amino[4-(ethylthio)phenyl]methyl}piperidine-1-carboxylate (917382-52-6) + tert-butyl (R*)-2-{(S*)-amino[4-(ethylthio)phenyl]methyl}piperidine-1-carboxylate (917382-52-6)

Guidance literature:

tert-butyl 2-{(Z)-[(tert-butylsulfinyl)imino]methyl}piperidine-1-carboxylate; 4-(ethylthio)phenylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 1h;

With ammonia; water; ammonium chloride; In tetrahydrofuran;

upstream raw materials:

1-bromo-4-ethylthiobenzene

magnesium

Downstream raw materials:

tert-butyl (R*)-2-{(R*)-amino[4-(ethylthio)phenyl]methyl}piperidine-1-carboxylate

tert-butyl (R*)-2-{(S*)-amino[4-(ethylthio)phenyl]methyl}piperidine-1-carboxylate

Refernces

• 1、 -. "Methanediphosphonate derivative, its manufacturing process and its pharmaceutical applications". . . Retrieved 2008/06/13.