30506-30-0

Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-4-(ethylthio)benzene is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones. Its unique chemical structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Bromo-4-(ethylthio)benzene is utilized as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these products enhances their effectiveness in controlling pests and weeds, thereby improving crop yields and food security.
Used in Dye Industry:
1-Bromo-4-(ethylthio)benzene is employed in the dye industry as a precursor for the synthesis of various dyes. Its chemical properties enable the development of dyes with improved colorfastness, brightness, and stability, which are essential for various applications, including textiles, plastics, and printing inks.
Used in Organic Synthesis:
As a reagent in organic synthesis, 1-Bromo-4-(ethylthio)benzene plays a crucial role in the preparation of various chemical compounds. Its reactivity allows for the formation of new bonds and the modification of existing ones, facilitating the synthesis of complex organic molecules with diverse applications.
Used in Chemical Compound Preparation:
1-Bromo-4-(ethylthio)benzene serves as a building block for the preparation of a wide range of chemical compounds. Its unique structure and reactivity make it an invaluable component in the synthesis of specialty chemicals, fine chemicals, and other advanced materials.
Safety Precautions:
Due to its toxic nature, 1-Bromo-4-(ethylthio)benzene poses risks if ingested or inhaled and may cause irritation to the skin, eyes, and respiratory system. It is also flammable, necessitating careful storage and handling in well-ventilated areas to minimize the risk of accidents and exposure.

InChI:InChI=1/C8H9BrS/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 106-53-6 para-bromobenzenethiol 
• 97-93-8 triethylaluminum 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 161573-70-2 <(4-bromophenylsulfinyl)(metoxycarbonyl)methylene>triphenylphosphorane 
• 161573-75-7 <(4-bromophenylsulfinyl)(etoxycarbonyl)methylene>triphenylphosphorane 
• 64-67-5 diethyl sulfate 
• 622-38-8 Ethyl phenyl sulfide 
• 30506-29-7 1-bromo-4-(ethylsulfinyl)benzene 
• 75-03-6 ethyl iodide 
• 93-89-0 benzoic acid ethyl ester 
• 5335-84-2 bis(4-bromophenyl)disulfide 
• 589-87-7 1,4-bromoiodobenzene 
• 75168-73-9 4-bromobenzenesulfonyl chloride 

Downstream Products

• 53104-02-2 N-tert-Butyl-N-(4-ethylsulfanyl-phenyl)-hydroxylamine 
• 74-85-1 ethene 
• 65662-88-6 phenyl(4-bromophenyl)sulfide 
• 145349-76-4 [4-(ethylsulfanyl)phenyl]boronic acid 
• 151426-22-1 bis(4-ethylthiophenyl)disulfide 
• 917382-51-5 4-(ethylthio)phenylmagnesium bromide 
• 26732-20-7 4-bromo-(ethylsulfonyl)benzene 
• 360775-83-3 2-(4-ethylthiobenzyl)phenol 
• 1186233-79-3 3β-(4-ethylthiophenyl)tropane-2β-carboxylic acid methyl ester 
• 874910-40-4 trimethyl-4-(ethylthio-phenyl) stannane 
• 1606131-44-5 3-(4-(ethylthio)phenyl)imidazo[1,2-a]pyrazine 
• 1606131-66-1 3-(4-(ethylthio)phenyl)-5-(pyridin-3-yl)imidazo[1,2-a]pyrazine 
• 1606131-67-2 3-(4-(ethylthio)phenyl)-5-(2-methoxypyridin-4-yl)imidazo[1,2-a]pyrazine 
• 1606131-68-3 4-(3-(4-(ethylthio)phenyl)imidazo[1,2-a]pyrazin-5-yl)isoquinoline 

Relevant academic research and scientific papers

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

Production of Alkyl Aryl Sulfides from Aromatic Disulfides and Alkyl Carboxylates via a Disilathiane–Disulfide Interchange Reaction

The results of this study show that disilathiane is an effective mediator in the synthesis of alkyl aryl sulfides with disulfides and alkyl carboxylates. Mechanistic studies suggest that disilathiane promotes cleavage of the sulfur–sulfur bond of disulfides to generate thiosilane as a key intermediate. Diselenides were also applicable to this transformation to produce the corresponding selenides.

Copper-Catalyzed Three-Component Coupling Reaction of Aryl Iodides, a Disilathiane, and Alkyl Benzoates Leading to a One-Pot Synthesis of Alkyl Aryl Sulfides

A copper-catalyzed three-component coupling reaction of aryl iodides, hexamethyldisilathiane and alkyl benzoates leading to alkyl aryl sulfides has been demonstrated. A disilathiane acted as both a sulfur source and a promoter of the sulfidation, and the alkyl moiety of the alkyl benzoate was effectively introduced on one side of the sulfide. Moreover, we found that the protocol can be expanded to the preparation of ethyl phenyl selenide with diphenyl diselenide.

Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics

Halogenated aromatic compounds are the cores of many pharmaceutical, agricultural and chemical products but they are commonly prepared using electrophilic halogenation reactions in non-green chlorinated solvents under harsh conditions. A separate problem happens in the aromatic halogenation of thioarenes because they readily undergo oxidative side-reactions. Herein we report an environmentally benign electrophilic bromination of aromatics using an indole-catalytic protocol, which is suitable for a wide range of substrates including thioarenes.

MODULATORS OF ROR-GAMMA

Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF ROR-GAMMA

Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions co

DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORγ. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

Dihydropyrrolopyridine inhibitors of ROR-gamma

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORγ. Also provided are pharmaceutical compositions co

OXAZOLIDINONE HYDROXAMIC ACID COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

This invention pertains generally to treating bacterial infections using organic compounds of Formula I. In certain aspects, the invention pertains to treating infections caused by Gram-negative bacteria. (I) wherein X, Y, R1, R2, R3, R4 and R5 and defined herein.