Technology Process of 5-(prop-1-ynyl)pyridin-3-ylboronic acid
There total 3 articles about 5-(prop-1-ynyl)pyridin-3-ylboronic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-bromo-5-(prop-1-yn-1-yl)pyridine;
With
n-butyllithium; Triisopropyl borate;
In
tetrahydrofuran; hexane; toluene;
at -40 - -20 ℃;
for 1.5h;
With
hydrogenchloride; water;
In
tetrahydrofuran; hexane; toluene;
- Guidance literature:
-
3-bromo-5-(prop-1-yn-1-yl)pyridine; Triisopropyl borate;
With
n-butyllithium;
In
2-methyltetrahydrofuran; toluene;
at -60 ℃;
for 1.5h;
With
hydrogenchloride; water;
In
2-methyltetrahydrofuran; toluene;
at -50 - 25 ℃;
for 0.333333h;
With
sodium hydroxide;
In
2-methyltetrahydrofuran; water; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; tetrabutyl ammonium fluoride / tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
2.1: n-butyllithium; Triisopropyl borate / toluene; tetrahydrofuran / 1.42 h / -78 - 20 °C / Inert atmosphere
2.2: 1 h / 20 °C
2.3: pH 7 - 8
With
n-butyllithium; Triisopropyl borate; tetrabutyl ammonium fluoride; triethylamine;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; toluene;
