(R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

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Chemical Name:(R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one
CAS No.:1383846-83-0
Molecular Formula:C₃₀H₂₅FN₄O
Molecular Weight:476.553
Hs Code.:

Synonyms:(R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

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Chemical Property of (R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

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Technology Process of (R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

There total 5 articles about (R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 917471-30-8
5-(prop-1-ynyl)pyridin-3-ylboronic acid

: 1383847-15-1
(R)-5-(3-amino-1-(3-bromophenyl)-4-fluoro-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

: 1383846-83-0
(R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

Guidance literature:: With potassium carbonate; sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid; In 2-methyltetrahydrofuran; water; for 2h; Product distribution / selectivity; Reflux; Inert atmosphere;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1383846-83-0
(R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; copper(l) iodide / toluene / Inert atmosphere; Reflux

2.1: n-butyllithium / toluene; 2-methyltetrahydrofuran / 1.5 h / -60 °C

2.2: 0.33 h / -50 - 25 °C

3.1: potassium carbonate / sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid / water; 2-methyltetrahydrofuran / 2 h / Reflux; Inert atmosphere

With n-butyllithium; potassium carbonate; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid; tetrabutyl ammonium fluoride; In 2-methyltetrahydrofuran; water; toluene;

Reference yield:

: 917772-69-1
3-bromo-5-(prop-1-yn-1-yl)pyridine

: 1383846-83-0
(R)-5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / toluene; 2-methyltetrahydrofuran / 1.5 h / -60 °C

1.2: 0.33 h / -50 - 25 °C

2.1: potassium carbonate / sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid / water; 2-methyltetrahydrofuran / 2 h / Reflux; Inert atmosphere

With n-butyllithium; potassium carbonate; sodium tetrachloropalladate(II); 3-(di-tert-butylphosphino)-propane-1-sulfonic acid; In 2-methyltetrahydrofuran; water; toluene;