Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 4-[(1R)-4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxy methyl)benzonitrile (1:1)

Base Information

Chemical Name:Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 4-[(1R)-4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxy methyl)benzonitrile (1:1)
CAS No.:917483-01-3
Molecular Formula:C20H23FN2O2.C20H18O8
Molecular Weight:728.771
Hs Code.:

Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with
4-[(1R)-4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxy
methyl)benzonitrile (1:1)

Synonyms:

Suppliers and Price of Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 4-[(1R)-4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxy methyl)benzonitrile (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 4-[(1R)-4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxy methyl)benzonitrile (1:1)

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 4-[(1R)-4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxy methyl)benzonitrile (1:1)

There total 6 articles about Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with 4-[(1R)-4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxy methyl)benzonitrile (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32634-68-7
(2S,3S)-di-4-toluoyltartaric acid

: 103146-25-4,219861-18-4,481047-48-7
4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

: 917483-01-3,128173-53-5,912452-31-4
(R)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-hydroxymethylbenzonitrile, salt with (+)-O,O'-di-p-toluoyltartaric acid

Guidance literature:: In isopropyl alcohol; at 20 - 45 ℃; Heating;

Reference yield:

: 32634-68-7
(2S,3S)-di-4-toluoyltartaric acid

: 103146-25-4,219861-18-4,481047-48-7
4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

: 128173-53-5,912452-31-4
(S)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-hydroxymethylbenzonitrile, salt with (+)-O,O'-di-p-toluoyltartaric acid

: 917483-01-3,128173-53-5,912452-31-4
(R)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-hydroxymethylbenzonitrile, salt with (+)-O,O'-di-p-toluoyltartaric acid

Guidance literature:: In propan-1-ol; toluene; at 20 - 40 ℃; Product distribution / selectivity;

Reference yield:

: 5407-04-5
3-(dimethylamino)propyl chloride hydrochloride

: 917483-01-3,128173-53-5,912452-31-4
(R)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-hydroxymethylbenzonitrile, salt with (+)-O,O'-di-p-toluoyltartaric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / water / 0 - 5 °C

1.2: 4 h / 100 - 110 °C / Reflux

2.1: tetrahydrofuran / 0.25 h / -5 °C

2.2: 0.5 h / -5 - 20 °C

2.3: pH 2

3.1: isopropyl alcohol / 3 h / 20 - 45 °C

With potassium hydroxide; In tetrahydrofuran; water; isopropyl alcohol;