5407-04-5Relevant articles and documents
Preparation method of N,N-dimethylaminochloropropane hydrochloride
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Paragraph 0028-0039, (2020/06/05)
The invention belongs to the technical field of drug intermediate synthesis, and in particular, relates to a preparation method of N,N-dimethylaminochloropropane hydrochloride. The preparation methodcomprises the steps: by taking chloropropene and dimethylamine as raw materials, carrying out aza-Michael addition under the action of a catalyst, separating and purifying to obtain an N,N-dimethylaminochloropropane solution after the reaction is finished, and carrying out acidification salifying reaction to obtain the N,N-dimethylaminochloropropane hydrochloride. The preparation method has the advantages of high reaction speed, high conversion rate, good selectivity, simple post-treatment and the like, the product purity is 99.0% or above, and the molar yield is 88% or above.
Side chain impacts on pH- and thermo-responsiveness of tertiary amine functionalized polypeptides
Xiao, Chunsheng,Cheng, Yilong,Zhang, Yu,Ding, Jianxun,He, Chaoliang,Zhuang, Xiuli,Chen, Xuesi
, p. 671 - 679 (2014/02/14)
The systemic investigation of the structural impacts of side chains on the pH- and thermo-responsiveness of tertiary amine functionalized poly(l-glutamate)s (TA-PGs) was carried out. The TA-PGs polymers were effectively synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(γ-propargyl-l-glutamate) (PPLG). Turbimetric measurements were performed to characterize the pH- and temperature-induced phase transition of TA-PGs in aqueous solution, which suggested a structural dependence of the properties on the N-substituted groups and the "linkers" between 1,2,3-triazole ring and the tertiary amine groups in the side chains. In detail, the pH responsive properties of TA-PGs were basically determined by the hydrophobicity of the N-substituted groups in the side chains and the pH transition point (pHt) decreased as the increasing hydrophobicity of the N-substituted groups, while the temperature-responsiveness of TA-PGs were affected by either the N-substituted groups or the "linkers." TA-PGs with a moderate N-substituted amine group (e.g., DEA, PR, and PD) or a branched "linker" (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the LCST-type phase transition tuned by pH variation. These structure-property relationships revealed in this study would help to develop the applications of TA-PGs in smart drug delivery systems. Copyright
INDENOISOQUINOLINONE DERIVATIVES, MANUFACTURING METHOD AND MEDICAL USE THEREOF
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Paragraph 0058; 0059, (2013/04/13)
Indenoisoquinolinone derivatives (I), the manufacturing method and the medical use thereof, which belong to pharmaceutical chemistry and organic chemistry field, are disclosed. These compounds can be used for treating several medical symptoms related to postmenopausal syndrome, uterine fibers deterioration and aortic smooth muscle cells proliferation, especially ER-(+) depend breast cancer. Meanwhile, these compounds can also be used for treating glioma and lung cancer, and have inhibiting effect on tumor metastasis effect on tumor metastasis.
