Technology Process of Benzamide,
N-[3-[[[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-[(trifluoro
methyl)thio]phenyl]amino]carbonyl]phenyl]-N-methyl-
There total 7 articles about Benzamide,
N-[3-[[[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-[(trifluoro
methyl)thio]phenyl]amino]carbonyl]phenyl]-N-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium dithionite; sodium hydrogencarbonate / tetra(n-butyl)ammonium hydrogensulfate / tert-butyl methyl ether; water / 10 h / 20 °C
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C
3.1: pyridine / 8 h / 90 °C
3.2: 6 h / 20 °C
With
pyridine; N-Bromosuccinimide; sodium dithionite; sodium hydrogencarbonate;
tetra(n-butyl)ammonium hydrogensulfate;
In
tert-butyl methyl ether; water; N,N-dimethyl-formamide;
- Guidance literature:
-
2-bromo-4-heptafluoroisopropyl-6-(trifluoromethylthio)aniline; C15H12ClNO2;
With
pyridine;
at 90 ℃;
for 8h;
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 6 h / 20 - 35 °C
2.1: potassium hydroxide / acetone / 4 h / 20 °C / Heating / reflux
3.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 90 °C
4.1: pyridine / 8 h / 90 °C
4.2: 6 h / 20 °C
With
pyridine; potassium hydroxide; sodium hydroxide; thionyl chloride;
In
water; N,N-dimethyl-formamide; acetone; toluene;
