Technology Process of D-Serine,
O-(1,1-dimethylethyl)-N-[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[[2-(4-fluoro
phenyl)-2-oxoethyl]thio]-4-oxo-2-azetidinyl]phenoxy]acetyl]-,
1,1-dimethylethyl ester
There total 6 articles about D-Serine,
O-(1,1-dimethylethyl)-N-[2-[4-[(2R,3R)-1-(4-fluorophenyl)-3-[[2-(4-fluoro
phenyl)-2-oxoethyl]thio]-4-oxo-2-azetidinyl]phenoxy]acetyl]-,
1,1-dimethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[4-((2R,3R)-3-{[(5,5-dimethyl-2-phenyl-1,3-dioxan-2-yl)methyl]thio}-4-oxo-1-phenylazetidin-2-yl)phenoxy]acetic acid; (R)-2-amino-3-tert-butoxy-propionic acid tert-butyl ester hydrochloride;
With
4-methyl-morpholine;
In
dichloromethane;
for 0.0833333h;
With
(1,1,1-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate;
In
dichloromethane;
for 3h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / toluene / 20 °C / Heating / reflux
2.1: lithium hydroxide; water / tetrahydrofuran / 19 h / 0 °C
2.2: pH 6
3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.33 h / 0 °C
3.2: 70 h / 20 °C
4.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.5 h / 0 °C
4.2: 0.83 h / -40 - 0 °C
5.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C
5.2: 18 h / 45 °C
6.1: methanol; water; triethylamine / 48 h / 50 °C
7.1: 4-methyl-morpholine / dichloromethane / 0.08 h
7.2: 3 h
With
4-methyl-morpholine; titanium(IV) isopropylate; methanol; dmap; lithium hydroxide; water; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; triethylamine; dicyclohexyl-carbodiimide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.33 h / 0 °C
1.2: 70 h / 20 °C
2.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.5 h / 0 °C
2.2: 0.83 h / -40 - 0 °C
3.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C
3.2: 18 h / 45 °C
4.1: methanol; water; triethylamine / 48 h / 50 °C
5.1: 4-methyl-morpholine / dichloromethane / 0.08 h
5.2: 3 h
With
4-methyl-morpholine; titanium(IV) isopropylate; methanol; dmap; water; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; triethylamine; dicyclohexyl-carbodiimide;
In
dichloromethane; toluene;
![[4-((2R,3R)-3-{[(5,5-dimethyl-2-phenyl-1,3-dioxan-2-yl)methyl]thio}-4-oxo-1-phenylazetidin-2-yl)phenoxy]acetic acid](/Databaselist/images/loading.webp)
