66560-19-8

Basic information

• Product Name: Acetic acid, [(2-oxo-2-phenylethyl)thio]-, ethyl ester
• CAS NO: 66560-19-8
• Molecular Formula: C12H14O3S
• Molecular Weight: 238.307
• Mol File: 66560-19-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Acetic acid, [(2-oxo-2-phenylethyl)thio]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [(2-oxo-2-phenylethyl)thio]-, ethyl ester(66560-19-8)
• EPA Substance Registry System: Acetic acid, [(2-oxo-2-phenylethyl)thio]-, ethyl ester(66560-19-8)

Safety Data

• Hazardous Substances Data: 66560-19-8(Hazardous Substances Data)

Upstream product

• 532-27-4 1-chloroacetophenone 
• 623-51-8 ethyl 2-sulfanylacetate 
• 64-17-5 ethanol 
• 22536-46-5 2-((2-oxo-2-phenylethyl)thio)acetic acid 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 96989-39-8 (<thio>methylene)-N-methylmethanaminium chloride 
• 87234-44-4 ethyl <(1-iminoethyl)thio>acetate hydrochloride 

Downstream Products

• 96631-00-4 Mercapto-(5-trimethylsilanyl-furan-2-yl)-acetic acid ethyl ester 
• 153784-04-4 ethyl 2-(2-oxo-2-phenylethylsulfonyl)acetate 
• 153784-53-3 6-Benzoyl-1-oxo-3,5-diphenyl-1λ⁴-thiomorpholine-2-carboxylic acid ethyl ester 

Relevant articles and documents

Continuous Flow Synthesis of 2H-Thiopyrans via thia-Diels–Alder Reactions of Photochemically Generated Thioaldehydes

Herein, we report a novel protocol for the photochemical generation of thioaldehydes in a continuous flow process which were in situ reacted with electron rich 1,3-butadienes in thia-Diels–Alder reactions. A broad range of 3,6-dihydro-2H-thiopyrans were formed as products in much higher yields and productivities as compared to classical batch processes. Moreover, greatly reduced reaction times and a facile large-scale preparation of products were achieved by fully exploiting the advantages of continuous flow technology.

Dichloroacetophenone Derivatives: A Class of Bioconjugation Reagents for Disulfide Bridging

A mild and biocompatible method for the construction of disulfide bridging in peptides using dichloroacetophenone derivatives is developed. This method is highly selective (chemo, diastereo, regio, etc.) and atom economic and works under biocompatible reaction conditions (metal-free, water, pH 7, rt, etc.).

1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors

A novel series of 1,2,3-thiadiazole thioacetanilide (TTA) derivatives have been designed, synthesized and evaluated for its anti-HIV activities in MT-4 cells. Some derivatives proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentrations. Among them, 2-[4-(2,4-dichlorophenyl)-1,2,3-thiadiazol-5-ylthio]-N-(2-nitrophenyl)acetamide 7d2 was identified as the most promising compound (EC50 = 0.059 ± 0.02 μM, CC50 > 283.25 μM, SI > 4883). The structure-activity relationship (SAR) of these novel structural congeners is discussed. Crown Copyright