Technology Process of 5,11-Dioxa-2,8-diazatridecanedioic acid,
2,3,8,9-tetramethyl-4,7,10-trioxo-6,12-dipentyl-, 1-(1,1-dimethylethyl)
13-(phenylmethyl) ester, (3S,6R,9S,12R)-
There total 15 articles about 5,11-Dioxa-2,8-diazatridecanedioic acid,
2,3,8,9-tetramethyl-4,7,10-trioxo-6,12-dipentyl-, 1-(1,1-dimethylethyl)
13-(phenylmethyl) ester, (3S,6R,9S,12R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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917613-38-8
benzyl (R)‐2‐(((6S,9R,12S)‐2,2,5,6,11,12‐hexamethyl‐4,7,10‐trioxo‐9‐pentyl‐3,8‐dioxa‐5,11‐diazatridecan‐13‐oyl)oxy)heptanoate
- Guidance literature:
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With
N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
dichloromethane;
for 1h;
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917613-38-8
benzyl (R)‐2‐(((6S,9R,12S)‐2,2,5,6,11,12‐hexamethyl‐4,7,10‐trioxo‐9‐pentyl‐3,8‐dioxa‐5,11‐diazatridecan‐13‐oyl)oxy)heptanoate
- Guidance literature:
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Multi-step reaction with 3 steps
1: 100 percent / EDCI; DMAP / CH2Cl2 / 1.5 h / 0 - 20 °C
2: H2 / Pd/C / ethyl acetate / 1 h / 20 °C
3: 6.26 g / DIPEA; PyBrop / CH2Cl2 / 1 h / 0 °C
With
dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
DOI:10.1021/ol0623365
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917613-38-8
benzyl (R)‐2‐(((6S,9R,12S)‐2,2,5,6,11,12‐hexamethyl‐4,7,10‐trioxo‐9‐pentyl‐3,8‐dioxa‐5,11‐diazatridecan‐13‐oyl)oxy)heptanoate
- Guidance literature:
-
Multi-step reaction with 2 steps
1: H2 / Pd/C / ethyl acetate / 1 h / 20 °C
2: 6.26 g / DIPEA; PyBrop / CH2Cl2 / 1 h / 0 °C
With
hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
DOI:10.1021/ol0623365