917613-27-5Relevant articles and documents
Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approaches
ōmura, Satoshi,Arai, Takahiro,Hirose, Tomoyasu,Masuda, Kei,Monma, Souichi,Murashima, Norifumi,Noguchi, Yoshihiko,Satake, Yudai,Shiomi, Kazuro,Sunazuka, Toshiaki,Watanabe, Akito
, (2020)
Intracellular Ca+ release channel ryanodine receptors play a critical role in excitable tissue. They represent a highly attractive drug target to promote the possible development of selective insecticides and useful agriculture chemicals. The symmetrical 24-membered cyclic depsipeptide verticilide demonstrates selective inhibition of ryanodine-ryanodine receptor binding. Solid phase peptide synthesis and hydrophobic anchor molecule processes are practical approaches for synthesizing such compounds, and are efficient and economical methods for discovering potent candidate insecticidal compounds. Herein we describe the total synthesis of verticilde using these practical synthetic approaches.
NOVEL CYCLIC DEPSIPEPTIDE DERIVATIVES AND HARMFUL ORGANISM CONTROL AGENTS COMPRISING THE SAME
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, (2017/08/26)
An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisom
NOVEL CYCLIC DEPSIPEPTIDE DERIVATIVE AND PEST CONTROL AGENT COMPRISING SAME
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Paragraph 0379-0380, (2017/09/14)
An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisom
