(2S,5S)-5-phenylpyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S,5S)-5-phenylpyrrolidine-2-carboxylic acid
CAS No.:917615-20-4
Molecular Formula:C₁₁H₁₃NO₂
Molecular Weight:191.23
Hs Code.:
European Community (EC) Number:824-868-2
DSSTox Substance ID:DTXSID40512172
Wikidata:Q76422942

Synonyms:(2S,5S)-5-phenylpyrrolidine-2-carboxylic acid;917615-20-4;L-Proline, 5-phenyl-, (5S)-;(5S)-5-Phenyl-L-proline;SCHEMBL197425;DTXSID40512172;AKOS037651211;CS-16130;CS-0089879;D72124;EN300-189057;EN300-264485;rac-(2R,5R)-5-phenylpyrrolidine-2-carboxylic acid

Suppliers and Price of (2S,5S)-5-phenylpyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (2S,5S)-5-phenylpyrrolidine-2-carboxylic acid

Chemical Property:

XLogP3:-0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:191.094628657
Heavy Atom Count:14
Complexity:211

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1C2=CC=CC=C2)C(=O)O
Isomeric SMILES:C1C[C@H](N[C@@H]1C2=CC=CC=C2)C(=O)O

Technology Process of (2S,5S)-5-phenylpyrrolidine-2-carboxylic acid

There total 5 articles about (2S,5S)-5-phenylpyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 174311-02-5
2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester

: 917615-20-4
C₁₁H₁₃NO₂

: 25860-44-0
2-phenyl-pyrrolidine-2-carboxylic acid

Guidance literature:: 2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester; With sec.-butyllithium; (-)-sparteine; In diethyl ether; cyclohexane; at -78 ℃; for 6h; Inert atmosphere;

carbon dioxide; In diethyl ether; cyclohexane; at -78 - 20 ℃;

With hydrogenchloride; water; In diethyl ether; cyclohexane; enantioselective reaction;
DOI:10.1021/ol800109s

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 174311-02-5
2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester

: 25860-44-0
2-phenyl-pyrrolidine-2-carboxylic acid

: 203645-40-3,917615-20-4
C₁₁H₁₃NO₂

Guidance literature:: 2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester; With sec.-butyllithium; (1R,2R)-N,N'-bis-(3,3-dimethyl-butyl)-N,N'-dimethyl-cyclohexane-1,2-diamine; In diethyl ether; cyclohexane; at -78 ℃; for 6h; Inert atmosphere;

carbon dioxide; In diethyl ether; cyclohexane; at -78 - 20 ℃;

With hydrogenchloride; water; In diethyl ether; cyclohexane; enantioselective reaction;
DOI:10.1021/ol800109s