(+)-Bufuralol

Base Information

Chemical Name:(+)-Bufuralol
CAS No.:64100-61-4
Molecular Formula:C16H23 N O2
Molecular Weight:261.364
Hs Code.:
UNII:TZ5STY38MD
ChEMBL ID:CHEMBL251642
Nikkaji Number:J227.845F
Wikidata:Q27290490
Mol file:64100-61-4.mol

Synonyms:(+)-Bufuralol;(R)-Bufuralol;Bufuralol, (+)-;TZ5STY38MD;64100-61-4;UNII-TZ5STY38MD;BUFURALOL, (R)-;CHEMBL251642;2-Benzofuranmethanol, alpha-(((1,1-dimethylethyl)amino)methyl)-7-ethyl-, (+)-;Q27290490;2-BENZOFURANMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-7-ETHYL-, (.ALPHA.R)-

Suppliers and Price of (+)-Bufuralol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
R-BUFURALOL 95.00%
5MG
$ 505.08

Total 0 raw suppliers

Chemical Property of (+)-Bufuralol

Chemical Property:

Boiling Point:393.2°Cat760mmHg
Flash Point:191.6°C
PSA：45.40000
Density:1.066g/cm³
LogP:3.80760
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:261.172878976
Heavy Atom Count:19
Complexity:287

Purity/Quality:: R-BUFURALOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O
Isomeric SMILES:CCC1=CC=CC2=C1OC(=C2)[C@@H](CNC(C)(C)C)O

Technology Process of (+)-Bufuralol

There total 21 articles about (+)-Bufuralol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 75-64-9
tert-butylamine

: (R)-7-ethyl-2-oxiranyl-benzofuran

: 1233816-69-7
C₁₆H₂₃NO₂

: 64100-61-4
(+)-Bufuralol

Guidance literature:: for 30h; regioselective reaction; Reflux; Neat (no solvent);
DOI:10.1021/jo100936f

Reference yield: 73.0%

: 1256291-77-6
2-(tert-butylamino)-1-(7'-ethylbenzofuran-2'-yl)ethanone

: 64100-61-4
(+)-Bufuralol

Guidance literature:: With formic acid; RhCl[(R,R)-TsDPEN](C₅Me₅); triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetasy.2010.07.004

Reference yield: 56.0%

: 75-64-9
tert-butylamine

: 537693-72-4
(S)-(+)-2-chloro-1-(7-ethylbenzofuran-2-yl)ethanol

: 64100-61-4
(+)-Bufuralol

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; for 7h; Heating;
DOI:10.1016/S0957-4166(03)00019-3